CAJ | 학술논문

目的：探讨抗病毒治疗对 HBV DNA阳性肝癌患者术后临床转归的影响。方法2008年至2013年我院共收治50例接受肝癌根治切除手术治疗的HBV DNA阳性肝癌患者，将这些患者分为观察组和对照组，每组25例。对照组患者单纯手术治疗，观察组患者手术切除联合拉米夫定抗病毒治疗。结果术后6个月观察组患者的AST、ALT、TBil水平均较对照组显著降低，Alb 水平较对照组增高（P＜0．05）；术后3个月和6个月观察组患者的 HBV DNA、Child-Pugh评分均较对照组显著降低（P＜0．05）；观察组患者的存活中位数明显较对照组大，1～2年、2～3年、3年以上无瘤生存率均较对照组显著升高（P＜0．05）。结论抗病毒治疗能够有效改善手术治疗的 HBV DNA阳性肝癌患者的预后。
목적：탐토항병독치료대 HBV DNA양성간암환자술후림상전귀적영향。방법2008년지2013년아원공수치50례접수간암근치절제수술치료적HBV DNA양성간암환자，장저사환자분위관찰조화대조조，매조25례。대조조환자단순수술치료，관찰조환자수술절제연합랍미부정항병독치료。결과술후6개월관찰조환자적AST、ALT、TBil수평균교대조조현저강저，Alb 수평교대조조증고（P＜0．05）；술후3개월화6개월관찰조환자적 HBV DNA、Child-Pugh평분균교대조조현저강저（P＜0．05）；관찰조환자적존활중위수명현교대조조대，1～2년、2～3년、3년이상무류생존솔균교대조조현저승고（P＜0．05）。결론항병독치료능구유효개선수술치료적 HBV DNA양성간암환자적예후。
Objective To investigate the impact of antiviral therapy on the prognosis of HBV-DNA positive hepatocellular carcinoma patients after surgical treatment. Methods Fifty HBV-DNA positive hepatocellular carcinoma patients after curative resection in our hospital from 2008 to 2013 were enrolled,which were divided into observation group and control group (25 cases in each group).The patients in control group were given surgery alone,while the patients in observation group were given surgical resection in combination with lamivudine antiviral therapy. ResultsCompared to control group,the AST,ALT and TBil levels of observation group in 6 months were significantly lower, while the Alb level was significantly higher(t= 2.571,P<0.05);The HBV DNA,Child-Pugh scores in 3 months and 6 months were significantly lower(t= 2.365,P<0.05);There was obviously higher median survival rate of disease-free survival rates for 1~2 years,2~3 years and more than 3 years in observation group,(χ2 = 0.024,P<0.05).Conclusions Antiviral therapy can improve the prognosis of HBV-DNA positive hepatocellular carcinoma patients after surgical treatment.