CAJ | 학술논문

心血管疾病患病率高、治愈率低，已成为导致死亡的首位疾病，其发生发展是多基因参与的多步骤、多阶段、体内外因素相互作用的复杂过程。西药作用靶点明确、途径单一、起效迅速，中药具有多成分、多靶点、多途径、持久温和的作用特点，二者联合应用在复杂疾病、慢性疾病的治疗方面能优势互补、协同增效、减少不良反应。本文重点对中西药联用治疗心血管疾病的原则和策略进行了探讨，总结出“中药为主、西药为辅，西药为主、中药为辅，中西药并重”的联合用药规律，以期为临床用药和新药研发工作者提供参考。
심혈관질병환병솔고、치유솔저，이성위도치사망적수위질병，기발생발전시다기인삼여적다보취、다계단、체내외인소상호작용적복잡과정。서약작용파점명학、도경단일、기효신속，중약구유다성분、다파점、다도경、지구온화적작용특점，이자연합응용재복잡질병、만성질병적치료방면능우세호보、협동증효、감소불량반응。본문중점대중서약련용치료심혈관질병적원칙화책략진행료탐토，총결출“중약위주、서약위보，서약위주、중약위보，중서약병중”적연합용약규률，이기위림상용약화신약연발공작자제공삼고。
Cardiovascular disease is characterized by the high prevalence and low cure rate , and has become the leading cause of death . Its development is a complex progress involving multiple steps , multiple phases and multiple factors .The western medicine can act on one target for one disease and has a certain efficacy .Traditional Chinese medicine ( TCM ) can act on multiple targets and pathways , which causes a lasting and mild effect .The combinatorial application of Chinese and Western medicine can treat the disease from many ways to enhance the efficacy and reduce the side effects .This paper focuses on the strategies of integrated application of Chinese and Western medicine for cardiovascular diseases , and presents three strategies which are "TCM as the major , Western medicine as the mi-nor;Western medicine as the major , TCM as the minor;Chinese and western medicine equally important"so as to provide a reference for the clinical use of drugs and new drug research and development .