CAJ | 학술논문

目的：研究红元颗粒的抗炎镇痛作用。方法：观察其对二甲苯致小鼠耳廓肿胀、冰醋酸致小鼠腹腔毛细血管通透性增高、角叉菜胶致大鼠足跖肿胀、棉球诱导大鼠肉芽肿、冰醋酸致小鼠扭体反应及小鼠热板实验的抑制作用。结果：红元颗粒可以明显抑制二甲苯致小鼠耳廓肿胀（P＜0.05），降低冰醋酸致小鼠腹腔毛细血管通透性增加（P＜0.05），减轻角叉菜胶致大鼠足跖肿胀（P＜0.05），抑制棉球肉芽肿增生（P＜0.01或P＜0.05），显著减轻热刺激引起的小鼠疼痛（P＜0.05）；减少小鼠扭体次数（ P＜0.01）。结论：红元颗粒具有显著的抗炎镇痛作用。
목적：연구홍원과립적항염진통작용。방법：관찰기대이갑분치소서이곽종창、빙작산치소서복강모세혈관통투성증고、각차채효치대서족척종창、면구유도대서육아종、빙작산치소서뉴체반응급소서열판실험적억제작용。결과：홍원과립가이명현억제이갑분치소서이곽종창（P＜0.05），강저빙작산치소서복강모세혈관통투성증가（P＜0.05），감경각차채효치대서족척종창（P＜0.05），억제면구육아종증생（P＜0.01혹P＜0.05），현저감경열자격인기적소서동통（P＜0.05）；감소소서뉴체차수（ P＜0.01）。결론：홍원과립구유현저적항염진통작용。
Objective: To study anti-inflammatory and analgesic effects of Hongyuan granule .Methods: The inhibitory effects were studied by observing xylene-induced swelling ear in mice , acetic acid-induced increase of abdominal capillary permeability in mice , car-rageenin-induced paw edema and cotton ball-induced proliferation of granuloma in rats , hot-induced pain and acetic acid-induced writ-hing in mice.Results:Hongyuan granule significantly reduced swelling ear in mice (P<0.05), decreased abdominal capillary permea-bility in mice (P<0.05), evidently relieved paw edema in rats (P<0.05), and remarkably inhibited proliferation of granuloma in rats (P<0.01 or P<0.05), notably alleviated pain induced by hot plate (P<0.05), as well as obviously reduced the writhing times in mice (P<0.05).Conclusion:Hongyuan granule has obvious anti-inflammatory and analgesic effects .