CAJ | 학술논문

目的：研究肺与大肠LPS信号通路变化的相关性。方法：将实验大鼠随机分为生理组、高氧组、低氧组、限食组和限水组，通过测定肺与大肠中TLR4、MD2和CD14的变化观察肺与大肠LPS信号通路的相关性。结果：高氧组和低氧组中肺部TLR4和MD2增高时，肠部也有所增高（P＜0.05），限食组和限水组中肠部TLR4和MD2增高时，肺部亦有增高（P＜0.05）。结论：可以认为肺与大肠在LPS信号通路TLR4和MD2中有相关的协同识别。
목적：연구폐여대장LPS신호통로변화적상관성。방법：장실험대서수궤분위생리조、고양조、저양조、한식조화한수조，통과측정폐여대장중TLR4、MD2화CD14적변화관찰폐여대장LPS신호통로적상관성。결과：고양조화저양조중폐부TLR4화MD2증고시，장부야유소증고（P＜0.05），한식조화한수조중장부TLR4화MD2증고시，폐부역유증고（P＜0.05）。결론：가이인위폐여대장재LPS신호통로TLR4화MD2중유상관적협동식별。
Objective:To study LPS signal path changes of lung and large intestine .Methods:Mice were randomly divided into physio-logical group , hyperoxia group , hypoxia group , diet restriction group , water restriction group .The LPS signal path ’ s correlation of lung and large intestine was observed detecting changes of variation of TLR 4, MD2 and CD14 in lung and large intestine .Results: When TLR4 and MD2 in the lungs of hyperoxia group and hypoxia group increased , they also increased in the large intestines .When TLR4 and MD2 in the large intestines of diet restriction group and water restriction group increased , they also increased in the lungs .Conclusion:Lung and large intestine can be thought to have related synergy identification in TLR 4 and MD2 of LPS signal path .