CAJ | 학술논문

目的：观察通腑泻肺方对ALI/ARDS大鼠肺、肠功能的影响，为“肺与大肠相表里”理论提供实验证据。方法：健康SD大鼠30只，随机分为3组，正常组、模型组和治疗组，采用尾静脉注射油酸加内毒素方法造成ALI/ARDS模型，治疗组给予通腑泻肺中药，于实验第7天检测分析各组大鼠肺功能、肠屏障功能指标。结果：1）与正常组比较，模型组大鼠肺顺应性显著降低、吸气和呼气阻力显著升高（P＜0.01），治疗后肺顺应性、吸气阻力有所改善；2）模型组大鼠肠组织中ocdudin蛋白表达较正常组明显降低（P＜0.01），治疗后显著升高（P＜0.05）；SIgA含量较正常组明显升高（P＜0.01），治疗后显著降低（P＜0.05）。结论：除肺通气功能障碍外，ALI/ARDS大鼠肠屏障功能同时受损。通腑泻肺中药能改善肺通气障碍，保护肠黏膜屏障功能。
목적：관찰통부사폐방대ALI/ARDS대서폐、장공능적영향，위“폐여대장상표리”이론제공실험증거。방법：건강SD대서30지，수궤분위3조，정상조、모형조화치료조，채용미정맥주사유산가내독소방법조성ALI/ARDS모형，치료조급여통부사폐중약，우실험제7천검측분석각조대서폐공능、장병장공능지표。결과：1）여정상조비교，모형조대서폐순응성현저강저、흡기화호기조력현저승고（P＜0.01），치료후폐순응성、흡기조력유소개선；2）모형조대서장조직중ocdudin단백표체교정상조명현강저（P＜0.01），치료후현저승고（P＜0.05）；SIgA함량교정상조명현승고（P＜0.01），치료후현저강저（P＜0.05）。결론：제폐통기공능장애외，ALI/ARDS대서장병장공능동시수손。통부사폐중약능개선폐통기장애，보호장점막병장공능。
Objective:To observe the effects of Tongfu Xiefei Herbs on lung and large intestinal function in ALI /ARDS rats, then pro-vide experimental basis for ALI/ARDS lung and large intestine concurrent therapy .Methods:Thirty healthy SD rats were randomly di-vided into 3 groups:control group , model group , treatment group .The ARDS rats was established by intravenous injecting oleic acid plus endotoxin in caudal vein , and treatment group were treated with Tongfu Xiefei herbs .The indicators of lung and intestinal function in each group were observed after 7 days.Results:1)Compared with control group, the lung compliance of model group was obviously decreased;the aspiratory and expiratory resistance were obviously increased (P<0.01).The lung function of treatment group improved . 2)Occludin protein expression in large intestine of model group were obviously decreased than that of control group (P<0.01),and were significantly increased after treatment (P<0.05).The SIgA of model group were obviously increased than control group (P<0.01),and were significantly decreased after treatment (P<0.05).Conclusion:With ventilation dysfunction, ALI/ARDS intestinal barrier function was damaged at the same time .Tongfu Xiefei herbs could improve the lung function and protect intestinal barrier function .