CAJ | 학술논문

极小胚胎样干细胞( very small embryonic-like stem cells, VSELs)是美国路易斯维尔大学Kucia 研究小组从小鼠骨髓和人脐带血中分离出一种具有类似胚胎干细胞生物特性的多潜能成体干细胞。与胚胎干细胞相似的外表---细胞形态及表面标志、以及相似的内在---多分化潜能决定了VSELs一出现就被细胞替代疗法视为最有潜力的种子细胞,本文就VSELs的研究历程及在眼科干细胞治疗视网膜退行性疾病中的临床意义作一综述。
겁소배태양간세포( very small embryonic-like stem cells, VSELs)시미국로역사유이대학Kucia 연구소조종소서골수화인제대혈중분리출일충구유유사배태간세포생물특성적다잠능성체간세포。여배태간세포상사적외표---세포형태급표면표지、이급상사적내재---다분화잠능결정료VSELs일출현취피세포체대요법시위최유잠력적충자세포,본문취VSELs적연구역정급재안과간세포치료시망막퇴행성질병중적림상의의작일종술。
Very small embryonic-like stem cells( VSELs) is a rare population of pluripotent adult stem cells, whose biological nature is similar to that of embryonic stem cells, firstly identified in murine bone marrow ( BM) and human cord blood ( CB ) by Kucia and his group in University of Louisville. They have similar outlook to embryonic stem cells such as cell morphology and markers and similar inner pluripotent characteristics which make them be the most potential seed cells in the cell replacement therapy. In this review, we will focus on research advance about VSELs and clinical significance in the stem cell transplantation treatment of retinal degenerative diseases.