CAJ | 학술논문

原发性胆汁性肝硬化（PBC）以肝内小胆管的损伤为特征，但其损伤机制尤其是B细胞免疫在其中发挥的作用尚不明确。从B细胞和浆细胞在PBC肝组织中的分布、B细胞清除、PBC血清中异常增高的IgM产生机制及其组织器官来源、线粒体抗体的产生机制以及在胆管损伤中的可能作用、PBC中特征性的自身抗体等方面，回顾了B细胞免疫在PBC发病机制中的可能作用。通过以上分析，认为B细胞免疫的确在PBC的发病机制中发挥了重要作用，但仍有很多关键的问题尚未得到阐明。
원발성담즙성간경화（PBC）이간내소담관적손상위특정，단기손상궤제우기시B세포면역재기중발휘적작용상불명학。종B세포화장세포재PBC간조직중적분포、B세포청제、PBC혈청중이상증고적IgM산생궤제급기조직기관래원、선립체항체적산생궤제이급재담관손상중적가능작용、PBC중특정성적자신항체등방면，회고료B세포면역재PBC발병궤제중적가능작용。통과이상분석，인위B세포면역적학재PBC적발병궤제중발휘료중요작용，단잉유흔다관건적문제상미득도천명。
Primary biliary cirrhosis (PBC)is characterized by injury of small intrahepatic bile ducts,but its mechanism,especially the role of B cell immunity in this disease,remains unclear.The possible role of B cell immunity in the pathogenesis of PBC is reviewed from the fol-lowing aspects:distribution of B cells and plasma cells in the liver tissues of PBC patients,clearance of B cells,mechanism of abnormal in-crease in serum IgM and its sources among PBC patients,mechanism of production of antimitochondrial antibodies and their possible func-tions in bile duct injury,and typical autoantibodies in PBC.B cell immunity is considered to play a significant role in the pathogenesis of PBC,but there are still many key problems to be clarified.