浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2014年
7期
585-586,589
,共3页
高血压性脑出血%纳洛酮%醒脑静%脑水肿%血肿%神经功能
高血壓性腦齣血%納洛酮%醒腦靜%腦水腫%血腫%神經功能
고혈압성뇌출혈%납락동%성뇌정%뇌수종%혈종%신경공능
Hypertensive cerebral hemorrhage%Naloxone%Xingnaojing injection%Brain edema%Hematoma%Neuro-logical function
目的：观察纳洛酮联用醒脑静治疗高血压性脑出血的临床疗效及对血肿的影响。方法根据随机数字表法将120例高血压性脑出血患者分为对照组、纳洛酮组、醒脑静组和联合治疗组，每组30例。对照组采用常规方法治疗，纳洛酮组、醒脑静组和联合治疗组在此基础上加用纳洛酮、醒脑静和两种药物联合治疗。观察并比较患者治疗前和治疗后第3、7、15和30天的血肿量、脑水肿指数、神经功能缺损评分。结果在治疗前和治疗后第3天，对照组、纳洛酮组、醒脑静组和联合治疗组间血肿量、脑水肿指数和神经功能缺损评分比较差异均无统计学意义（均P＞0.05）；在治疗后第7、15和30天，对照组、纳洛酮组、醒脑静组和联合治疗组间血肿量、脑水肿指数和神经功能缺损评分比较差异均有统计学意义（均P＜0.05）。联合治疗组血肿量、脑水肿指数和神经功能缺损评分较纳洛酮组和醒脑静组显著低于对照组（均P＜0.05）。结论纳洛酮联用醒脑静治疗高血压性脑出血可以更好地促进血肿吸收，减轻脑水肿，改善神经功能缺损。
目的：觀察納洛酮聯用醒腦靜治療高血壓性腦齣血的臨床療效及對血腫的影響。方法根據隨機數字錶法將120例高血壓性腦齣血患者分為對照組、納洛酮組、醒腦靜組和聯閤治療組，每組30例。對照組採用常規方法治療，納洛酮組、醒腦靜組和聯閤治療組在此基礎上加用納洛酮、醒腦靜和兩種藥物聯閤治療。觀察併比較患者治療前和治療後第3、7、15和30天的血腫量、腦水腫指數、神經功能缺損評分。結果在治療前和治療後第3天，對照組、納洛酮組、醒腦靜組和聯閤治療組間血腫量、腦水腫指數和神經功能缺損評分比較差異均無統計學意義（均P＞0.05）；在治療後第7、15和30天，對照組、納洛酮組、醒腦靜組和聯閤治療組間血腫量、腦水腫指數和神經功能缺損評分比較差異均有統計學意義（均P＜0.05）。聯閤治療組血腫量、腦水腫指數和神經功能缺損評分較納洛酮組和醒腦靜組顯著低于對照組（均P＜0.05）。結論納洛酮聯用醒腦靜治療高血壓性腦齣血可以更好地促進血腫吸收，減輕腦水腫，改善神經功能缺損。
목적：관찰납락동련용성뇌정치료고혈압성뇌출혈적림상료효급대혈종적영향。방법근거수궤수자표법장120례고혈압성뇌출혈환자분위대조조、납락동조、성뇌정조화연합치료조，매조30례。대조조채용상규방법치료，납락동조、성뇌정조화연합치료조재차기출상가용납락동、성뇌정화량충약물연합치료。관찰병비교환자치료전화치료후제3、7、15화30천적혈종량、뇌수종지수、신경공능결손평분。결과재치료전화치료후제3천，대조조、납락동조、성뇌정조화연합치료조간혈종량、뇌수종지수화신경공능결손평분비교차이균무통계학의의（균P＞0.05）；재치료후제7、15화30천，대조조、납락동조、성뇌정조화연합치료조간혈종량、뇌수종지수화신경공능결손평분비교차이균유통계학의의（균P＜0.05）。연합치료조혈종량、뇌수종지수화신경공능결손평분교납락동조화성뇌정조현저저우대조조（균P＜0.05）。결론납락동련용성뇌정치료고혈압성뇌출혈가이경호지촉진혈종흡수，감경뇌수종，개선신경공능결손。
Objective To assess the efficacy of naloxone combined with Xingnaojing injection in treatment of hypertensive cerebral hemorrhage. Methods One hundred and twenty patients with hypertensive cerebral hemorrhage admitted in hospital were randomly divided into control group, naloxone group, Xingnaojing group and combined treatment group with 30 cases in each. Patients in control group received conventional treatment, and patients in naloxone, xingnaojing, combined treatment groups received additional naloxone, Xingnaojing, naloxone with Xingnaojing treatment, respectively. The changes of hematoma volume, cerebral edema index and neurological function defect scores were compared before and after treatment. Results The differences of hematoma volume, cerebral edema index and neurological function defect score were not significant before and 3d after treatment among 4 groups (al P>0.05);the significant differences were observed at d 7, 15 and 30 after treatment (al P<0.05). Compared with naloxone and Xingnaojing groups, the hematoma volume, cerebral edema index and neurological function defect score in combined treatment group were improved more markedly than those in control group (al P<0.05). Conclusion Combined administration of naloxone and Xingnaojing injection is more effective in absorbing hematoma, relieving brain edema and improving neurological function defect than single drug treatment in patients with hypertensive cerebral hemorrhage.
