CAJ | 학술논문

目的：探讨诱发家族性尿道下裂的因素和治疗方法。方法：对2系5例家族性尿道下裂患者分别行一期尿道成形术、阴茎腹曲矫正术治疗。结果：5例中2例术后出现尿瘘，分别于术后6个月行尿瘘修补术、4年后行二期带蒂阴囊正中皮瓣尿道成形术，均治愈。结论：家族性尿道下裂基因易感因素发挥着主要作用，手术矫正是有效的治疗方法。
목적：탐토유발가족성뇨도하렬적인소화치료방법。방법：대2계5례가족성뇨도하렬환자분별행일기뇨도성형술、음경복곡교정술치료。결과：5례중2례술후출현뇨루，분별우술후6개월행뇨루수보술、4년후행이기대체음낭정중피판뇨도성형술，균치유。결론：가족성뇨도하렬기인역감인소발휘착주요작용，수술교정시유효적치료방법。
Objective To explore the risk factors for hypospadias. Methods Five cases of familial hypo-spadias were retrospectively studied by analyzing the related information of hypospadias phenotype,accompanying other genital malformations,the history of familial hereditary disease family formation,living environment,etc. Results Case 1 and case 2 were first cousins. Case 3 and case 4 were brothers,without other brothers and sis-ters. Case 5 was a cousin of case 3 and case 4,and had only one sister.They had common uncle and aunt,whose familial generation were all females free from deformation.The 5 cases:lived in countryside;without causative fac-tor inducing abnormal growth of urethra;non-consanguineous marriage of grandparent and parents;without family medical history of external deformation;natural gravidity as well as their parents;their parents wre free from relat-ed drug-taking in pregnacy. Conclusion The causative factors of the familial hypospadias are multiple,but the potential effects of genetic susceptibility play the key role.For partial familial hypospadias,the potential ef-fects of genetic susceptibility may be the single and independent factor.