CAJ | 학술논문

目的：研究深静脉血栓形成（DVT）中Th1/Th2细胞因子的变化规律。方法：选取DVT患者66例，按病程分为1~3 d组、4~7 d组、8~15 d组和16~30 d组，观察Th1/Th2相关因子TNF-α、IFN-γ、IL-4、IL-10水平。结果：DVT患者TNF-α、IFN-γ、IL-4、IL-10均较对照组明显升高，1~3 d组、4~7 d组的IFN-γ/IL-4比值较对照组升高，8~15 d组和16~30 d组IFN-γ/IL-4比值较对照组降低。结论：DVT中存在Th1/Th2的分化失衡，Th1/Th2细胞因子可以作为临床病情评估和疗效评价的指标。
목적：연구심정맥혈전형성（DVT）중Th1/Th2세포인자적변화규률。방법：선취DVT환자66례，안병정분위1~3 d조、4~7 d조、8~15 d조화16~30 d조，관찰Th1/Th2상관인자TNF-α、IFN-γ、IL-4、IL-10수평。결과：DVT환자TNF-α、IFN-γ、IL-4、IL-10균교대조조명현승고，1~3 d조、4~7 d조적IFN-γ/IL-4비치교대조조승고，8~15 d조화16~30 d조IFN-γ/IL-4비치교대조조강저。결론：DVT중존재Th1/Th2적분화실형，Th1/Th2세포인자가이작위림상병정평고화료효평개적지표。
Objective To research the change regulation of Th1/Th2 in deep venous thrombosis(DVT) and to provide an intervention therapy. Methods Sixty six patients with DVT were selected to be divided into four groups according to the disease duration (group I=1-3days; group II =4-7days; group III =8-15days; group IV = 16-30days) to observe the levels of TNF-α,IFN-γ,IL-4 and IL-10, the four Th1/Th2-Related Cytokines. Results Clinical research showed that the levels of TNF-α,IFN-γ,IL-4 and IL-10 of DVT patients were high-er than those in control group(P<0.05,P<0.01).The ratios of IFN-γ and IL-4 in group I and group II were higher than those in control group while the ratios of IFN-γ and IL-4 in Group III and group IV obtained re-verse results. Conclusion Th1/Th2 differentiation imbalance exists during the course of DVT. The Th1/Th2 cytokine might be used as an clinical indicator for estimating the extent of disease and evaluation of therapeutic efficiency.