CAJ | 학술논문

[目的]综述中药有效组分防治心肌缺血再灌注损伤机制研究进展。[方法]通过查询近5年来的相关文献，综述近年来干预心肌缺血再灌注损伤效果明显的多种中药组分对心肌再灌注损伤作用机制研究概况。[结果]多种中药有效组分可以通过：①增加内源性抗氧化酶或抗氧化物质的活性或/和合成，减少氧化产物的生成，减轻氧化机制造成的再灌注损伤；②通过增加Ca2+Mg2+-ATP酶及Na+K+-ATP酶的活性，调节离子转运，减轻钙离子超载；③减少IL-1、TNF-α等炎症因子释放，减轻炎症反应；④调节细胞凋亡相关分子的表达，抑制心肌细胞凋亡；⑤调节舒血管活性物质前列环素（PGI2）和缩血管活性物质血栓素A2（TXA2）释放，改善内皮功能等途径发挥抗心肌缺血再灌注损伤作用。[结论]中药有效组分可有效防治心肌缺血再灌注损伤，但目前研究存在受试物质量控制缺乏、重复性差、受试物各成分间相互作用机制不明、有效成分不清、药理作用机制研究有待深入等问题，今后研究应考虑中医药作用特点，结合现代医学研究进展，阐明中药在防治心肌缺血再灌注损伤中的物质基础和作用机制。
[목적]종술중약유효조분방치심기결혈재관주손상궤제연구진전。[방법]통과사순근5년래적상관문헌，종술근년래간예심기결혈재관주손상효과명현적다충중약조분대심기재관주손상작용궤제연구개황。[결과]다충중약유효조분가이통과：①증가내원성항양화매혹항양화물질적활성혹/화합성，감소양화산물적생성，감경양화궤제조성적재관주손상；②통과증가Ca2+Mg2+-ATP매급Na+K+-ATP매적활성，조절리자전운，감경개리자초재；③감소IL-1、TNF-α등염증인자석방，감경염증반응；④조절세포조망상관분자적표체，억제심기세포조망；⑤조절서혈관활성물질전렬배소（PGI2）화축혈관활성물질혈전소A2（TXA2）석방，개선내피공능등도경발휘항심기결혈재관주손상작용。[결론]중약유효조분가유효방치심기결혈재관주손상，단목전연구존재수시물질량공제결핍、중복성차、수시물각성분간상호작용궤제불명、유효성분불청、약리작용궤제연구유대심입등문제，금후연구응고필중의약작용특점，결합현대의학연구진전，천명중약재방치심기결혈재관주손상중적물질기출화작용궤제。
[Objective] Summarizing the effect of components from traditional Chinese medicine on mechanism in myocardial ischemia reperfusion injury. [Methods]By querying the nearly five years of related literature, summarizing the advances in studies on various traditional Chinese medicine effective components prevention and treatment for myocardial ischemia reperfusion injury.[Results] Traditional Chinese medicine effective components through the same or different ways play a role, for example,(1)antioxidant,(2)reduce calcium overload, (3)reduce inflammation reaction, (4)inhibit myocardial apoptosis , (5)improve endothelial function. [Conclusion] The review provides further research of traditional Chinese medicine in the prevention and treatment of myocardial ischemia reperfusion injury to provide the reference.