CAJ | 학술논문

microRNA （ miRNA）是真核生物中广泛存在的一类长21～23个核苷酸的非编码RNA分子，通过与靶基因mRNA的特异结合调节基因转录后表达，在调控细胞周期、生物体发育时序等方面起重要作用。 miR160、miR167和miR3903个miRNAs家族均为靶向ARF（ Auxin Response Factor）基因家族，预示着它们在行使调控功能的过程中既有相似性又有特异性。笔者详细阐述了miR160/miR167/miR390在植物发育过程中的调控作用及与其靶基因之间的相互调控关系，发现 miR160/miR167/miR390均在植物生长发育过程中发挥重要的作用，但miR160则侧重于调控胚胎和根的发育，miR167侧重于调控植物花和果实的发育，而miR390则对植物横向器官的发育具有调控作用，并且，miR160/miR167/miR390与其靶基因之间存在反馈调节作用。
microRNA （ miRNA）시진핵생물중엄범존재적일류장21～23개핵감산적비편마RNA분자，통과여파기인mRNA적특이결합조절기인전록후표체，재조공세포주기、생물체발육시서등방면기중요작용。 miR160、miR167화miR3903개miRNAs가족균위파향ARF（ Auxin Response Factor）기인가족，예시착타문재행사조공공능적과정중기유상사성우유특이성。필자상세천술료miR160/miR167/miR390재식물발육과정중적조공작용급여기파기인지간적상호조공관계，발현 miR160/miR167/miR390균재식물생장발육과정중발휘중요적작용，단miR160칙측중우조공배태화근적발육，miR167측중우조공식물화화과실적발육，이miR390칙대식물횡향기관적발육구유조공작용，병차，miR160/miR167/miR390여기파기인지간존재반궤조절작용。
MicroRNA ( miRNA) is endogenous and non-coding small RNA with 21-23 nucleotides, and it widely exits in eukaryotes. MiRNAs repress gene expression at post transcriptional level by acting on near-perfect complementary se-quences in mRNA coding region to guide cleavage and translational repression, and it plays an important role in regula-ting cell cycle and development timing of biology. Three miRNA families including miR160, miR167 and miR390 all tar-geting to ARF ( Auxin response factor) gene family have been reviewed, and which indicates that they fulfil the similar and differential function. For example, miR160/miR167/miR390 plays an important role in plant development. But miR160 focuses on regulating embryo and root development, miR167 focuses on the regulation of flowers and fruit devel-opment, and miR390 has remarkable effect on regulating plant lateral organ development. Moreover, feedback regulation exists between miR160/miR167/miR390 and their target genes.