广西医学
廣西醫學
엄서의학
GUANGXI MEDICAL JOURNAL
2014年
4期
413-415
,共3页
王海彦%廖品琥%熊滨%覃纲%李军%黄冰%仇晓文%胡东海%黄孔文
王海彥%廖品琥%熊濱%覃綱%李軍%黃冰%仇曉文%鬍東海%黃孔文
왕해언%료품호%웅빈%담강%리군%황빙%구효문%호동해%황공문
Toll样受体4%内含子%单核苷酸多态性%广西
Toll樣受體4%內含子%單覈苷痠多態性%廣西
Toll양수체4%내함자%단핵감산다태성%엄서
Toll-like receptor 4%Intron%Single nucleotide polymorphism%Guangxi
目的:探讨人类Toll样受体4(TLR4)基因内含子区单核苷酸多态性在广西人群中分布情况及其与不同人群的差异。方法采用单碱基延伸PCR技术和DNA测序方法检测196例健康广西人群(男115例,女81例)TLR4基因内含子区rs11536879A/G位点多态性,并与人类基因组计划研究的4个人群(欧洲、北京、日本、非洲)单核苷酸多态性分型数据进行对比。结果广西人群TLR4基因内含子区rs11536879A/G位点存在AA、GA、GG 3种基因型,其基因型及等位基因频率在男性、女性组间分布差异无统计学意义( P>0.05);广西人群TLR4基因内含子区rs11536879A/G位点基因型及等位基因频率与欧洲、非洲、日本人群比较,差异有统计学意义(P<0.05),而与北京人群比较,差异无统计学意义( P>0.05)。结论广西人群TLR4基因内含子区基因多态性的基因型及等位基因频率分布在男女性之间无明显差异,在不同地区人群之间存在明显差异。
目的:探討人類Toll樣受體4(TLR4)基因內含子區單覈苷痠多態性在廣西人群中分佈情況及其與不同人群的差異。方法採用單堿基延伸PCR技術和DNA測序方法檢測196例健康廣西人群(男115例,女81例)TLR4基因內含子區rs11536879A/G位點多態性,併與人類基因組計劃研究的4箇人群(歐洲、北京、日本、非洲)單覈苷痠多態性分型數據進行對比。結果廣西人群TLR4基因內含子區rs11536879A/G位點存在AA、GA、GG 3種基因型,其基因型及等位基因頻率在男性、女性組間分佈差異無統計學意義( P>0.05);廣西人群TLR4基因內含子區rs11536879A/G位點基因型及等位基因頻率與歐洲、非洲、日本人群比較,差異有統計學意義(P<0.05),而與北京人群比較,差異無統計學意義( P>0.05)。結論廣西人群TLR4基因內含子區基因多態性的基因型及等位基因頻率分佈在男女性之間無明顯差異,在不同地區人群之間存在明顯差異。
목적:탐토인류Toll양수체4(TLR4)기인내함자구단핵감산다태성재엄서인군중분포정황급기여불동인군적차이。방법채용단감기연신PCR기술화DNA측서방법검측196례건강엄서인군(남115례,녀81례)TLR4기인내함자구rs11536879A/G위점다태성,병여인류기인조계화연구적4개인군(구주、북경、일본、비주)단핵감산다태성분형수거진행대비。결과엄서인군TLR4기인내함자구rs11536879A/G위점존재AA、GA、GG 3충기인형,기기인형급등위기인빈솔재남성、녀성조간분포차이무통계학의의( P>0.05);엄서인군TLR4기인내함자구rs11536879A/G위점기인형급등위기인빈솔여구주、비주、일본인군비교,차이유통계학의의(P<0.05),이여북경인군비교,차이무통계학의의( P>0.05)。결론엄서인군TLR4기인내함자구기인다태성적기인형급등위기인빈솔분포재남녀성지간무명현차이,재불동지구인군지간존재명현차이。
Objective To investigate the distribution of single nucleotide polymorphism(SNP) of Toll-like receptor 4(TLR4) gene in Guangxi population ,and to discuss the difference among various groups .Methods Polymerase chain reaction-single base extension ( PCR-SBE ) and DNA sequencing method were used to analyze the rs 11536879A/G polymorphism of TLR4 gene at the intronic region among 196 healthy cases in Guangxi (115 male cases ,81 female cases ) which was compared with the data of other 4 populations(Hapmap-CEU,Hapmap-HCB,Hapmap-JPT,Hapmap-YRI) from the Human Genome Project group (Hapmap).Results There were genotypes of AA ,GA,GG in rs11536879A/G of TLR4 gene at the intronic region in Guangxi population , the frequencies of genotype and allele distribution of rs11536879A/G polymorphisms showed no significant difference between female and male groups (P>0.05).Guangxi population showed a significant difference in the frequencies of genotype and allele distribution of rs 11536879 A/G polymorphism in contrast with Hapmap-CEU,Hapmap-JPT and Hapmap-YRI(P<0.05),but showed no significant difference in contast with Hapmap-HCB(P>0.05).Conclusion The frequencies of genotype and allele distribution of genetic polymorphisms at the TLR 4 intronic region in Guangxi population show no significant difference between the male and the female ,but show a significant difference among different regions and races .