CAJ | 학술논문

国内外学者对发病隐匿、进展快、预后差、复发率高的卵巢恶性肿瘤做了大量研究，但其早期诊断率及生存率未见上升、死亡率未见降低，且死亡率居妇科恶性肿瘤首位，成为严重威胁妇女生命健康的主要肿瘤。微小RNA （miRNA）为新发现的非编码内源性小分子RNA，发现其调节人类近30%的基因表达，生物学特性为高度保守性、时序表达特异性和组织表达特异性，在卵巢癌中扮演重要角色。研究发现，miRNA参与卵巢癌肿瘤细胞的发生、侵袭转移过程，与卵巢癌的预后密切相关。综述miRNA与卵巢癌侵袭转移关系的最新研究进展。
국내외학자대발병은닉、진전쾌、예후차、복발솔고적란소악성종류주료대량연구，단기조기진단솔급생존솔미견상승、사망솔미견강저，차사망솔거부과악성종류수위，성위엄중위협부녀생명건강적주요종류。미소RNA （miRNA）위신발현적비편마내원성소분자RNA，발현기조절인류근30%적기인표체，생물학특성위고도보수성、시서표체특이성화조직표체특이성，재란소암중분연중요각색。연구발현，miRNA삼여란소암종류세포적발생、침습전이과정，여란소암적예후밀절상관。종술miRNA여란소암침습전이관계적최신연구진전。
Domestic and foreign scholars on the occult onset,rapid progression,poor prognosis,recurrence rate of malignant ovarian tumor did a lot of researches ,but the rate of early diagnosis and survival rate did not increase ,without reducing mortality,and the first mortality in gynecological malignant tumor,ovarian cancer become the main cancer seriously threatens women health life. miRNA is a non-coding endogenous small RNA newly found , regulating the expression of nearly 30%genes of human,its biological characteristics of specific expression in tissue,highly conservative and temporal expression play an important role in ovarian cancer. The study found that miRNA involved in the process of invasion and metastasis of ovarian cancer cells,but also closely related to the prognosis in patients with ovarian cancer. In order to understand the mechanism of invasion and metastasis of malignant ovarian cancer ,this review summarizes the new progress of miRNA and ovarian cancer.