CAJ | 학술논문

多肽药物因具有相对成本低，生物活性强，副作用小，不蓄积中毒，作用靶点专一等特点而被人们广泛应用。但天然存在的多肽类药物含量较少、纯度较低，无法满足临床的需求。经研究发现，通过体外合成的多肽药物具有合成周期短、生产量大等优势，能够有效克服天然多肽药物的不足，对于推广多肽类药物的应用有重要意义。本文对多肽类药物体外合成方法进行综述，为其今后的发展和临床应用提供参考。
다태약물인구유상대성본저，생물활성강，부작용소，불축적중독，작용파점전일등특점이피인문엄범응용。단천연존재적다태류약물함량교소、순도교저，무법만족림상적수구。경연구발현，통과체외합성적다태약물구유합성주기단、생산량대등우세，능구유효극복천연다태약물적불족，대우추엄다태류약물적응용유중요의의。본문대다태류약물체외합성방법진행종술，위기금후적발전화림상응용제공삼고。
Peptide drugs have been widely used for the low cost , high biological activity, low side effects, no accumula-tion of toxic, target specificity and other s .However, the natural peptide drugs have low concentration and low purity;can not meet the requirement of clinical applications .Synthetic peptide drugs have the priority of short synthetic cycle and large production volume , which are important for the promotion of clinical application of peptide drugs .Consulting the relevant literatures , this article intends to review the drugs synthesis and provide a reference for future drug development and clinical application .