大连医科大学学报
大連醫科大學學報
대련의과대학학보
JOURNAL OF DALIAN MEDICAL UNIVERSITY
2014年
2期
171-173
,共3页
突发性耳聋%山莨菪碱%高压氧%有效时间点%疗效
突髮性耳聾%山莨菪堿%高壓氧%有效時間點%療效
돌발성이롱%산랑탕감%고압양%유효시간점%료효
sudden deafness%anisodamine%hyperbaric oxygen%effective time%curative effect
目的：观察不同时间点高压氧联合山莨菪碱治疗突发性耳聋对疗效的影响。方法将166例采用高压氧治疗（ HBO）的突发性耳聋患者，分为山莨菪碱组88例与对照组78例，两组均给予常规药物治疗，山莨菪碱组每日治疗前30 min肌注山莨菪碱，比较不同时间点治疗前后听力的变化。结果在发病1天内开始治疗，山莨菪碱组38例，显效率90．48％；对照组28例，显效率80．00％；两组均可收到较好疗效；发病1天～1周内开始治疗，山莨菪碱组26例，显效率76．47％；对照组16例，显效率51．61％；山莨菪碱组比对照组效果好，差异有显著性意义（ P＜0．05）；发病2周后开始治疗，两组疗效均较差。结论高压氧联合山莨菪碱在有效时间点内治疗突发性耳聋，临床疗效肯定。
目的：觀察不同時間點高壓氧聯閤山莨菪堿治療突髮性耳聾對療效的影響。方法將166例採用高壓氧治療（ HBO）的突髮性耳聾患者，分為山莨菪堿組88例與對照組78例，兩組均給予常規藥物治療，山莨菪堿組每日治療前30 min肌註山莨菪堿，比較不同時間點治療前後聽力的變化。結果在髮病1天內開始治療，山莨菪堿組38例，顯效率90．48％；對照組28例，顯效率80．00％；兩組均可收到較好療效；髮病1天～1週內開始治療，山莨菪堿組26例，顯效率76．47％；對照組16例，顯效率51．61％；山莨菪堿組比對照組效果好，差異有顯著性意義（ P＜0．05）；髮病2週後開始治療，兩組療效均較差。結論高壓氧聯閤山莨菪堿在有效時間點內治療突髮性耳聾，臨床療效肯定。
목적：관찰불동시간점고압양연합산랑탕감치료돌발성이롱대료효적영향。방법장166례채용고압양치료（ HBO）적돌발성이롱환자，분위산랑탕감조88례여대조조78례，량조균급여상규약물치료，산랑탕감조매일치료전30 min기주산랑탕감，비교불동시간점치료전후은력적변화。결과재발병1천내개시치료，산랑탕감조38례，현효솔90．48％；대조조28례，현효솔80．00％；량조균가수도교호료효；발병1천～1주내개시치료，산랑탕감조26례，현효솔76．47％；대조조16례，현효솔51．61％；산랑탕감조비대조조효과호，차이유현저성의의（ P＜0．05）；발병2주후개시치료，량조료효균교차。결론고압양연합산랑탕감재유효시간점내치료돌발성이롱，림상료효긍정。
Objective To observe the effect of different time points of hyperbaric oxygen combined with anisodamine in the treatment of sudden deafness on curative effect .Methods A total of 166 patients with sudden deafness treated by hyperbaric oxygen ( HBO) were divided into anisodamine group of 88 cases and control group of 78 cases.The two groups were given routine drug treatment.In addition, the anisodamine group received intramuscular injection of anisodamine 30 minutes be-fore treatment.The changes of hearing before and after treatment were compared at different time points .Results Two groups had excellent curative effects when the treatment initiated within the first 24 hours.In anisodamine group of 38 ca-ses, the effective rate was 90.48%;in control group of 28 cases, the effective rate was 80%.Anisodamine group had bet-ter curative effects than control group within the first week , with significant difference (P<0.05).In anisodamine group of 26 cases, the effective rate was 76.47%;in control group of 16 cases, the effective rate was 51.61%.The outcome can not be improved in both groups if the treatment was initiated after 2 weeks.Conclusion Hyperbaric oxygen combined with anisodamine in the treatment of sudden deafness within the effective time has clinical curative effect affirmation .
