CAJ | 학술논문

肝纤维化的形成是一个多因素、多细胞参与的复杂过程，近来研究发现，结缔组织生长因子对促进纤维化的发生发展起正调节作用。结缔组织生长因子是一种多功能的分泌性多肽，可以调节细胞增殖、分化以及黏附等生物学活性，在肝组织损伤修复、细胞外基质合成、临床上肝纤维化的诊断及治疗等方面发挥重要作用。
간섬유화적형성시일개다인소、다세포삼여적복잡과정，근래연구발현，결체조직생장인자대촉진섬유화적발생발전기정조절작용。결체조직생장인자시일충다공능적분비성다태，가이조절세포증식、분화이급점부등생물학활성，재간조직손상수복、세포외기질합성、림상상간섬유화적진단급치료등방면발휘중요작용。
The formation of hepatic fibrosis is a complicated process involving multiple factors and cells .It has been found form recent research that connective tissue growth factor plays a positive regulatory role in promoting the occurrence and development of hepatic fibrosis .Connective tissue growth factor belongs to a family of secreting polypeptide , which can regulate cell proliferation , differentiation and adherence , etc.It also plays very important roles in hepatic tissue repair , ex-tracellular matrix synthesis , diagnosis and treatment of hepatic fibrosis in clinical settings , etc.