心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2014年
2期
197-199
,共3页
朱元州%胡量子%卢思稼%杜雄兵%常超%田莉%冯义柏
硃元州%鬍量子%盧思稼%杜雄兵%常超%田莉%馮義柏
주원주%호양자%로사가%두웅병%상초%전리%풍의백
冠状动脉疾病%肌钙蛋白%尼可地尔
冠狀動脈疾病%肌鈣蛋白%尼可地爾
관상동맥질병%기개단백%니가지이
Coronary artery disease%Troponin%Nicorandil
目的：探讨尼可地尔在持续性肌钙蛋白 I （TnI）弱阳性不稳定型心绞痛患者中的作用。方法：选择伴有持续性肌钙蛋白 I （TnI）弱阳性的不稳定性心绞痛患者111例，随机分为对照组（55例，接受常规治疗）和干预组（56例，在常规治疗基础上加用尼可地尔片（5mg，3次/d）；观察，比较两组患者治疗1周内胸痛缓解情况，3个月内因胸痛加重的再住院情况，1年内心源性死亡情况。结果：与对照组比较，干预组1周内两组症状缓解率显著上升（63.6％比91.1％，χ2＝11.97，P＝0.0005）；3个月内胸痛加重再发住院显著减少（56.4％比19.6％，χ2＝15.91，P＝0.0001）；但1年内两组心源性死亡率无显著差异（5.5％比8.9％，χ2＝0.50，P＝0.4792）。结论：尼可地尔可明显改善持续性TnI弱阳性不稳定型心绞痛患者的症状，而且减少患者因心绞痛加重的再住院率，但一年内死亡率两组没有明显差别。
目的：探討尼可地爾在持續性肌鈣蛋白 I （TnI）弱暘性不穩定型心絞痛患者中的作用。方法：選擇伴有持續性肌鈣蛋白 I （TnI）弱暘性的不穩定性心絞痛患者111例，隨機分為對照組（55例，接受常規治療）和榦預組（56例，在常規治療基礎上加用尼可地爾片（5mg，3次/d）；觀察，比較兩組患者治療1週內胸痛緩解情況，3箇月內因胸痛加重的再住院情況，1年內心源性死亡情況。結果：與對照組比較，榦預組1週內兩組癥狀緩解率顯著上升（63.6％比91.1％，χ2＝11.97，P＝0.0005）；3箇月內胸痛加重再髮住院顯著減少（56.4％比19.6％，χ2＝15.91，P＝0.0001）；但1年內兩組心源性死亡率無顯著差異（5.5％比8.9％，χ2＝0.50，P＝0.4792）。結論：尼可地爾可明顯改善持續性TnI弱暘性不穩定型心絞痛患者的癥狀，而且減少患者因心絞痛加重的再住院率，但一年內死亡率兩組沒有明顯差彆。
목적：탐토니가지이재지속성기개단백 I （TnI）약양성불은정형심교통환자중적작용。방법：선택반유지속성기개단백 I （TnI）약양성적불은정성심교통환자111례，수궤분위대조조（55례，접수상규치료）화간예조（56례，재상규치료기출상가용니가지이편（5mg，3차/d）；관찰，비교량조환자치료1주내흉통완해정황，3개월내인흉통가중적재주원정황，1년내심원성사망정황。결과：여대조조비교，간예조1주내량조증상완해솔현저상승（63.6％비91.1％，χ2＝11.97，P＝0.0005）；3개월내흉통가중재발주원현저감소（56.4％비19.6％，χ2＝15.91，P＝0.0001）；단1년내량조심원성사망솔무현저차이（5.5％비8.9％，χ2＝0.50，P＝0.4792）。결론：니가지이가명현개선지속성TnI약양성불은정형심교통환자적증상，이차감소환자인심교통가중적재주원솔，단일년내사망솔량조몰유명현차별。
Objective:To discuss effect of nicorandil on unstable angina patients With persistent Weakly positive for troponin I (TnI).Methods:A total of 111 unstable angina patients With persistent Weakly positive for TnI Were randomly divided into control group (received routine treatment,55 cases) and intervention group (received nic-orandil 5mg,3 times/d based on routine treatment,56 cases).The relief of chest pain in one Week,the recurrent hospitalization for chest pain aggravation in 3 months and the cardiac mortality rate in one year betWeen tWo groups Were observed in tWo groups. Results:Compared With control group,the relief of angina pectoris in one Week (63.6% vs. 91.1%,χ2=11.97,P=0.0005)significantly increased,re-hospitalization for chest pain aggravation in three months (56.4% vs.19.6%,χ2=15.91,P=0.0001)significantly decreased in intervention group;but cardiac mortality rate during one year betWeen tWo groups Was no significant difference (5.5% vs. 8.9%,χ2=0.50,P=0.4792).Conclusion:Nicorandil can significantly reduce the unstable angina and re-hospitalization for chest pain aggravation in patients With persistent Weakly positive for TnI,but there Was no significant difference in reducing mortality Within one year betWeen tWo groups.
