CAJ | 학술논문

目的：观察多烯磷脂酰胆碱治疗原发性肝癌（primary liver cancer, PLC）患者行经导管肝动脉化疗栓塞（trans-catheter arterial chemoembolization, TACE）后肝损伤的效果。方法66例PLC患者被随机分为治疗组和对照组，每组各33例，均行TACE治疗。TACE治疗前2天，对照组开始接受谷胱甘肽等药物常规保肝治疗，治疗组在对照组基础上加用多烯磷脂酰胆碱静脉滴注，930 mg/d。在药物治疗前和TACE治疗后第3天检测2组患者的TBIL、前白蛋白、ALT和AST水平。结果治疗组经多烯磷脂酰胆碱治疗后，TBIL、ALT和AST与对照组相比均显著改善（P均＜0.05）。结论多烯磷脂酰胆碱治疗PLC患者TACE相关性肝损伤效果较好。
목적：관찰다희린지선담감치료원발성간암（primary liver cancer, PLC）환자행경도관간동맥화료전새（trans-catheter arterial chemoembolization, TACE）후간손상적효과。방법66례PLC환자피수궤분위치료조화대조조，매조각33례，균행TACE치료。TACE치료전2천，대조조개시접수곡광감태등약물상규보간치료，치료조재대조조기출상가용다희린지선담감정맥적주，930 mg/d。재약물치료전화TACE치료후제3천검측2조환자적TBIL、전백단백、ALT화AST수평。결과치료조경다희린지선담감치료후，TBIL、ALT화AST여대조조상비균현저개선（P균＜0.05）。결론다희린지선담감치료PLC환자TACE상관성간손상효과교호。
Objective To investigate the therapeutic efficacy of polyene phosphatidylcholine on hepatic injury in patients with primary liver cancer (PLC) receiving transcatheter arterial chemoembolization (TACE). Methods A total of 66 PLC patients were randomized into a treatment group and a control group, with 33 patients in each group. Both the groups received TACE. Since two days before TACE, the control group began to receive routine liver-protecting therapy with drugs such as glutathione, while the treatment group received intravenous administration of polyene phosphatidylcholine, 930 mg daily, in addition to the routine liver-protecting therapy. The levels of TBIL, PA, ALT and AST were detected before drug therapy and on the 3rd day after giving TACE. Results As compared with the control group, TBIL, ALT and AST in the patients of the treatment group, who had received polyene phosphatidylcholine, significantly improved (P<0.05). Conclusion Treatment with polyene phosphatidylcholine has good effect on hepatic injury in PLC patients receiving TACE.