CAJ | 학술논문

目的：通过对慢性阻塞性肺疾病（ COPD）患者应用小剂量茶碱后，肺功能、6min步行试验、CAT评分等指标的检测，探讨小剂量茶碱对COPD患者预后的影响。方法应用随机分组、对照及自身对照的方法，将937例COPD患者分为治疗组（常规治疗＋茶碱缓释片0．1，2次/d）和对照组（常规治疗），对应用茶碱治疗前后的各项指标进行统计学比较。结果①治疗组的COPD患者经过90d的治疗，治疗后第1秒用力呼气容积实测值与预计值的百分比（ FEV1％预计值）及FEV1和用力肺活量实测值与预计值的百分比（ FEV1/FVC％）较治疗前明显提高；6MWT提高；CAT评分、mMRC评分下降（ P＜0．05）。②治疗后治疗组较对照组患者的上述指标均有改善（ P＜0．05）。结论应用小剂量茶碱可改善COPD患者的肺功能，提高患者的活动能力及生活质量，可能延缓疾病进展。
목적：통과대만성조새성폐질병（ COPD）환자응용소제량다감후，폐공능、6min보행시험、CAT평분등지표적검측，탐토소제량다감대COPD환자예후적영향。방법응용수궤분조、대조급자신대조적방법，장937례COPD환자분위치료조（상규치료＋다감완석편0．1，2차/d）화대조조（상규치료），대응용다감치료전후적각항지표진행통계학비교。결과①치료조적COPD환자경과90d적치료，치료후제1초용력호기용적실측치여예계치적백분비（ FEV1％예계치）급FEV1화용력폐활량실측치여예계치적백분비（ FEV1/FVC％）교치료전명현제고；6MWT제고；CAT평분、mMRC평분하강（ P＜0．05）。②치료후치료조교대조조환자적상술지표균유개선（ P＜0．05）。결론응용소제량다감가개선COPD환자적폐공능，제고환자적활동능력급생활질량，가능연완질병진전。
Objective To observe the effect of low-dose theophylline on the prognosis of patients with COPD through pulmonary function ,the six-minute walking test (6MWT),CAT scores,mMRC score.Methods Using random allocation ,controlled and self-control methods ,937 COPD patients were divided into treatment group ( conventional thera-py+oral theophylline 0.4g/day) and control group(conventional therapy).The applications of theophylline were com-pared between before and after treatment .Results ①Measuring the expiratory volume in one second (FEV1) and forced vital capacity(FVC) through lung function before and after treatment within 90 days,the two indexes were improved sig-nificantly in the treatment group of COPD patients (P<0.05).6MWT were improved;CAT scores,mMRC score were re-duced .②After therapy ,compared with control group ,patients in treatment group of the above indexes were improved ( P<0.05) .Conclusion Low-dose theophylline could improve the lung function of COPD patients ,improve the patient's activity ability and the quality of life ,may slow disease progression .