CAJ | 학술논문

目的：观察活动期类风湿关节炎（ RA）患者血脂特征及其临床意义。方法选取活动期RA患者（活动组）40例、非活动期RA患者（非活动组）36例与健康对照组30例，同时对受试者血清总胆固醇（ TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）及C-反应蛋白（CRP）、类风湿因子（RF）、红细胞沉降率（ESR）进行检测。结果与健康对照组比较，2组RA患者HDL-C、ApoA1显著降低（ P ＜0殮．01），ESR、CRP、RF升高（ P ＜0．01），且活动组较非活动组变化更明显（ P均＜0．01），而TC、TG、LDL-C、ApoB 3组间比较差异无统计学意义（ P﹥0．05）；HDL-C、ApoA1与CRP、ESR、RF均呈显著负相关（r ＝-0．634、r ＝-0．901、r ＝-0．485， r ＝-0．625、r ＝-0．520、r ＝-0．236， P ＜0．05或P ＜0．01）；TC、TG、LDL-C、ApoB与疾病活动性无明显相关（ P﹥0．05）。结论活动期RA患者体内HDL-C、ApoA1显著降低，这种变化与RA病情活动密切相关。
목적：관찰활동기류풍습관절염（ RA）환자혈지특정급기림상의의。방법선취활동기RA환자（활동조）40례、비활동기RA환자（비활동조）36례여건강대조조30례，동시대수시자혈청총담고순（ TC）、삼선감유（TG）、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）、재지단백A1（ApoA1）、재지단백B（ApoB）급C-반응단백（CRP）、류풍습인자（RF）、홍세포침강솔（ESR）진행검측。결과여건강대조조비교，2조RA환자HDL-C、ApoA1현저강저（ P ＜0렴．01），ESR、CRP、RF승고（ P ＜0．01），차활동조교비활동조변화경명현（ P균＜0．01），이TC、TG、LDL-C、ApoB 3조간비교차이무통계학의의（ P﹥0．05）；HDL-C、ApoA1여CRP、ESR、RF균정현저부상관（r ＝-0．634、r ＝-0．901、r ＝-0．485， r ＝-0．625、r ＝-0．520、r ＝-0．236， P ＜0．05혹P ＜0．01）；TC、TG、LDL-C、ApoB여질병활동성무명현상관（ P﹥0．05）。결론활동기RA환자체내HDL-C、ApoA1현저강저，저충변화여RA병정활동밀절상관。
Objective To observe the characteristics of serum lipids in activity rheumatoid arthritis ( RA) and inves-tigate its clinical significance.Methods Select active RA patients (active group) 40 cases, non-active RA patients (inactive group) 36 cases, and healthy control group of 30 patients, while the subjects serum total cholesterol ( TC), triglyceride (TG), high-density lipoprotein cholesterol ( HDL-C), low density lipoprotein cholesterol ( LDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and C reactive protein (CRP), rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) were detected.Results Compared with the healthy control group , two groups of RA patients'HDL-C, ApoA1 de-creased significantly ( P <0.01), ESR,CRP,RF increased significantly( P <0.01),and the active group changed more ob-vious than the inactivity group ( P <0.01) , and TC, TG, LDL-C, ApoB in 3 groups showed no statistically significant ( P >0.05);HDL-C, ApoA1 presented significant negative correlation with CRP , ESR, RF ( r =-0.634, r =-0.901, r =-0.485, r =-0.625, r =-0.520, r =-0.236, P <0.05 or P <0.01); TC, TG, LDL-C, ApoB and disease activity was not significant correlated ( P >0.05).Conclusion In the active phase of RA, serum HDL-C and ApoA1 levels decrease significantly, this change is closely related with the disease activity .