CAJ | 학술논문

表面等离子体共振（SPR）光学传感器能实现生物医学的快速、无标记、高精度检测，是生物化学分析的重要方法。研制了基于波长调制型的Kretschmann结构表面等离子体共振（SPR）生物传感系统，研究了在体溶液传感方式下的传感性能。利用不同浓度的乙醇和乙二醇溶液进行体溶液传感测试。实验结果表明，在折射率低时共振波长对折射率变化响应的灵敏度低，但响应的线性度高；随着折射率增大，共振波长对折射率的响应变化的灵敏度提高。在1.4070～1.430 RIU折射率范围内，灵敏度高达11487 nm · RIU -1。传感器的共振波长的稳定性为0.2138 nm ，可分辨最小折射率趋近10-6 RIU。所研制的波长调制型表面等离子共振传感器操作简单、灵敏度高、检测范围大，可实现浓度极低生物标记物的有效检测，在化学、生物传感领域有重要的应用。
표면등리자체공진（SPR）광학전감기능실현생물의학적쾌속、무표기、고정도검측，시생물화학분석적중요방법。연제료기우파장조제형적Kretschmann결구표면등리자체공진（SPR）생물전감계통，연구료재체용액전감방식하적전감성능。이용불동농도적을순화을이순용액진행체용액전감측시。실험결과표명，재절사솔저시공진파장대절사솔변화향응적령민도저，단향응적선성도고；수착절사솔증대，공진파장대절사솔적향응변화적령민도제고。재1.4070～1.430 RIU절사솔범위내，령민도고체11487 nm · RIU -1。전감기적공진파장적은정성위0.2138 nm ，가분변최소절사솔추근10-6 RIU。소연제적파장조제형표면등리자공진전감기조작간단、령민도고、검측범위대，가실현농도겁저생물표기물적유효검측，재화학、생물전감영역유중요적응용。
Surface plasmon resonance (SPR) is a rapid ,label-free ,high-precision technique of biological sensing and analysis . The investigation on the characteristics of provides theoretical basis and instructions for the applications of SPR . A Kretschmann-structure surface plasmon resonance (SPR) biosensor based on wavelength modulation was developed ,and also its sensing performances in the bulk solution was investigated .Measurements with different concentrations of bulk ethanol and eth-ylene glycol solutions show that the resonant wavelength shows a low sensitivity ,but a higher linear response to the change in refractive index (RI) ,when RI is relatively smaller .With increasing refractive index ,the sensitivity of resonance wavelength to changes in the refractive index increases .In the refractive index range of 1 .407 0~1 .430 RIU ,sensitivity reaches to 11 487 nm · RIU -1 .The sensor resonance wavelength stability is 0 .213 8 nm ,and the minimum resolution of refractive index approaches to 10-6 RIU .The advantages of the surface plasmon resonance sensor developed here results in simple operation ,high sensitivi-ty ,wide detection range ,low resolution ,makes it an important candidate in chemical and biological sensing .