CAJ | 학술논문

目的探讨超声药物电导入联合口服抗结核药物治疗颈部淋巴结结核的疗效.方法选取2010年1月至2012年12月首都医科大学附属北京胸科医院初治的颈淋巴结结核患者168例,完全随机分为观察组和对照组,各84例.2组均采用规范四联抗结核药物口服治疗,即异炯肼0.3g,1次/d;利福平0.45 g,1次/d;乙胺丁醇0.75 g,1次/d;吡嗪酰胺0.5g,3次/d.观察组另加局部药物超声电导入治疗,即采用利福平溶液(含注射用利福平0.3g,5 ml)敷于体表结核部位,超声电导仪导入30 min.疗程均为2个月.结果观察组治愈72例,显效6例,好转6例,治愈率为85.7％,总有效率为92.9％;对照组治愈19例,显效6例,好转10例,病变无明显变化40例,病情进展9例,治愈率为22.6％,总有效率为29.8％.观察组治愈率及总有效率均高于对照组,组间差异均有统计学意义(均P＜0.01).结论超声电导入联合规范抗结核药物治疗颈部淋巴结结核的效果优于单纯抗结核药物治疗.
목적 탐토초성약물전도입연합구복항결핵약물치료경부림파결결핵적료효.방법 선취2010년1월지2012년12월수도의과대학부속북경흉과의원초치적경림파결결핵환자168례,완전수궤분위관찰조화대조조,각84례.2조균채용규범사련항결핵약물구복치료,즉이형정0.3g,1차/d;리복평0.45 g,1차/d;을알정순0.75 g,1차/d;필진선알0.5g,3차/d.관찰조령가국부약물초성전도입치료,즉채용리복평용액(함주사용리복평0.3g,5 ml)부우체표결핵부위,초성전도의도입30 min.료정균위2개월.결과 관찰조치유72례,현효6례,호전6례,치유솔위85.7％,총유효솔위92.9％;대조조치유19례,현효6례,호전10례,병변무명현변화40례,병정진전9례,치유솔위22.6％,총유효솔위29.8％.관찰조치유솔급총유효솔균고우대조조,조간차이균유통계학의의(균P＜0.01).결론 초성전도입연합규범항결핵약물치료경부림파결결핵적효과우우단순항결핵약물치료.
Objective To investigate the efficacy of ultrasound-mediated drug delivery combined with oral anti-tuberculous (TB) drugs.Methods Totally 168 cases of initial tuberculosis treatment of cervical lymph nodes were randomly divided into observation group and control group.Both groups had standardized quadruple anti-TB drugs.The observation group also received ultrasound-mediated drug delivery including rifampicin solution for 2 months.Results The cure rate and total effective rate of the observation group was 85.7％ (72/84) and 92.9％ (78/84).The cure rate and total effective rate of the control group was 22.6％ (19/84) and 29.8％ (25/84) ; there was a statistically significant difference between the cure rates and the total effective rates in the two groups.Conclusion The efficacy of ultrasound-mediated drug delivery combined with oral anti-TB drugs is superior to solo anti-TB medication treatment.