临床荟萃
臨床薈萃
림상회췌
CLINICAL FOCUS
2014年
5期
531-533,534
,共4页
牛素贞%秦连菊%段和春%边亚%寇立巧
牛素貞%秦連菊%段和春%邊亞%寇立巧
우소정%진련국%단화춘%변아%구립교
糖尿病,2 型%血管成形术,气囊,冠状动脉%心肌缺血%C 反应蛋白质
糖尿病,2 型%血管成形術,氣囊,冠狀動脈%心肌缺血%C 反應蛋白質
당뇨병,2 형%혈관성형술,기낭,관상동맥%심기결혈%C 반응단백질
diabetes mellitus,type 2%angioplasty,balloon,coronary%myocardial ischemia%C-reactive protein
目的：探讨合并2型糖尿病的经皮冠状动脉介入治疗术(PCI)患者术后高敏 C 反应蛋白(hsCRP)水平及其与术后心血管事件发生的相关性。方法选择38例糖尿病 PCI 患者,及38例非糖尿病 PCI 患者,收集患者一般情况,PCI 手术前后 hsCRP 情况,手术后6个月内主要不良心脏事件(MACE)发生情况,分析术后72小时 hsCRP 水平与 MACE 的相关性。结果两组一般情况比较差异无统计学意义(P >0.05)。两组患者手术后 hsCRP 水平[(15.94±3.49)μg/L,(11.67±3.28)μg/L]明显高于手术前[(7.64±3.64)μg/L,(7.59±3.38)μg/L],差异有统计学意义(P <0.05),两组术前 hsCRP 水平差异无统计学意义[(7.64±3.64)μg/L vs (7.59±3.38)μg/L,P >0.05],术后糖尿病 PCI 组 hsCRP 水平明显高于非糖尿病 PCI 组,差异有统计学意义[(15.94±3.49)μg/L vs (11.67±3.28)μg/L,P <0.05]。术后6个月内糖尿病 PCI 组 MACE 发生率明显高于非糖尿病 PCI 组,差异有统计学意义[31.6%(12/38)vs 13.2%(5/38),P <0.05],糖尿病 PCI 组 MACE 中以心绞痛及非 Q 波心肌梗死发生比例高(均为13.2%),非糖尿病 PCI 组中以心绞痛发生比例最高(7.9%)。合并2型糖尿病患者血 hsCRP 水平与 MACE 发生呈正相关(r =0.467,P <0.05)。结论合并糖尿病的患者 PCI 术后早期炎症反应更为严重,可促进血管再狭窄的出现和 MACE 的发生。
目的：探討閤併2型糖尿病的經皮冠狀動脈介入治療術(PCI)患者術後高敏 C 反應蛋白(hsCRP)水平及其與術後心血管事件髮生的相關性。方法選擇38例糖尿病 PCI 患者,及38例非糖尿病 PCI 患者,收集患者一般情況,PCI 手術前後 hsCRP 情況,手術後6箇月內主要不良心髒事件(MACE)髮生情況,分析術後72小時 hsCRP 水平與 MACE 的相關性。結果兩組一般情況比較差異無統計學意義(P >0.05)。兩組患者手術後 hsCRP 水平[(15.94±3.49)μg/L,(11.67±3.28)μg/L]明顯高于手術前[(7.64±3.64)μg/L,(7.59±3.38)μg/L],差異有統計學意義(P <0.05),兩組術前 hsCRP 水平差異無統計學意義[(7.64±3.64)μg/L vs (7.59±3.38)μg/L,P >0.05],術後糖尿病 PCI 組 hsCRP 水平明顯高于非糖尿病 PCI 組,差異有統計學意義[(15.94±3.49)μg/L vs (11.67±3.28)μg/L,P <0.05]。術後6箇月內糖尿病 PCI 組 MACE 髮生率明顯高于非糖尿病 PCI 組,差異有統計學意義[31.6%(12/38)vs 13.2%(5/38),P <0.05],糖尿病 PCI 組 MACE 中以心絞痛及非 Q 波心肌梗死髮生比例高(均為13.2%),非糖尿病 PCI 組中以心絞痛髮生比例最高(7.9%)。閤併2型糖尿病患者血 hsCRP 水平與 MACE 髮生呈正相關(r =0.467,P <0.05)。結論閤併糖尿病的患者 PCI 術後早期炎癥反應更為嚴重,可促進血管再狹窄的齣現和 MACE 的髮生。
목적：탐토합병2형당뇨병적경피관상동맥개입치료술(PCI)환자술후고민 C 반응단백(hsCRP)수평급기여술후심혈관사건발생적상관성。방법선택38례당뇨병 PCI 환자,급38례비당뇨병 PCI 환자,수집환자일반정황,PCI 수술전후 hsCRP 정황,수술후6개월내주요불양심장사건(MACE)발생정황,분석술후72소시 hsCRP 수평여 MACE 적상관성。결과량조일반정황비교차이무통계학의의(P >0.05)。량조환자수술후 hsCRP 수평[(15.94±3.49)μg/L,(11.67±3.28)μg/L]명현고우수술전[(7.64±3.64)μg/L,(7.59±3.38)μg/L],차이유통계학의의(P <0.05),량조술전 hsCRP 수평차이무통계학의의[(7.64±3.64)μg/L vs (7.59±3.38)μg/L,P >0.05],술후당뇨병 PCI 조 hsCRP 수평명현고우비당뇨병 PCI 조,차이유통계학의의[(15.94±3.49)μg/L vs (11.67±3.28)μg/L,P <0.05]。술후6개월내당뇨병 PCI 조 MACE 발생솔명현고우비당뇨병 PCI 조,차이유통계학의의[31.6%(12/38)vs 13.2%(5/38),P <0.05],당뇨병 PCI 조 MACE 중이심교통급비 Q 파심기경사발생비례고(균위13.2%),비당뇨병 PCI 조중이심교통발생비례최고(7.9%)。합병2형당뇨병환자혈 hsCRP 수평여 MACE 발생정정상관(r =0.467,P <0.05)。결론합병당뇨병적환자 PCI 술후조기염증반응경위엄중,가촉진혈관재협착적출현화 MACE 적발생。
Objective To investigate the levels high sense C reactive protein(hsCRP)in patients with type 2 diabetes after percutaneous coronary intervention(PCI)and its correlation with postoperative cardiovascular events. Methods The study enrolled 38 PCI patients with diabetes mellitus,and 38 PCI patients without diabetic mellitus,the general data,hsCRP before and after PCI surgery,major adverse cardiac events (MACE)within six months after surgery of the patients were PCI collected,Spearman rank correlation analysis was used to illustrate the correlation between hsCRP level and MACE after for PCI 72 hours.Results The general conditions of two groups showed no significant difference(P >0.05).The hsCRP levels of two groups after PCI(1 5.94±3.49)μg/L,(1 1.67±3.28)μg/L were significantly higher than before PCI (7.64 ±3.64)μg/L,(7.59 ±3.38)μg/L(P <0.05).The postoperative hsCRP levels of diabetes PCI group (1 5.94±3.49)μg/L was significantly higher than that of non-diabetic PCI group (1 1.67± 3.28 )μg/L (P < 0.05 ).Within 6 months after PCI,the MACE of diabetic group 31.6% (12/38 )was significantly higher than that of non-diabetic group 13.2%(5/38)(P <0.05 ).In diabetes PCI group,MACE mainly presented with angina and non-Q-wave myocardial infarction(both 13.2%),while in non-diabetic group,MACE mainly with angina (7.9%).The blood hsCRP level of patients with type 2 diabetes mellitus was positively correlated with MACE(r =0.467,P <0.05 ).Conclusion Early inflammatory response in patients with type 2 diabetes mellitus is more severe,which can promote the emergence of restenosis and MACE.
