CAJ | 학술논문

目的：探讨荧光原位杂交和核基质蛋白22对膀胱尿路上皮癌诊断的价值，寻找一种敏感特异的无创性方法诊断膀胱癌。方法：对68例膀胱癌疑似患者的尿液标本同时进行荧光原位杂交、核基质蛋白22、尿脱落细胞学检测，同时，将3种方法结果与组织病理学诊断结果比较，评估它们对膀胱癌的临床诊断价值。结果：FISH、NMP22、尿脱落细胞学的敏感性分别为81．4％、86．0％、39．5％，特异性分别为84．0％、72．0％、96．0％，FISH联合NMP22检测的敏感性为79．1％、特异性为92．0％。结论：FISH-NMP22联合检测有较高的敏感性和特异性，其敏感性远高于细胞学检测，而特异性与细胞学检测相差甚小，联合检测较单一指标的检测对膀胱癌具有更高的诊断价值。
목적：탐토형광원위잡교화핵기질단백22대방광뇨로상피암진단적개치，심조일충민감특이적무창성방법진단방광암。방법：대68례방광암의사환자적뇨액표본동시진행형광원위잡교、핵기질단백22、뇨탈락세포학검측，동시，장3충방법결과여조직병이학진단결과비교，평고타문대방광암적림상진단개치。결과：FISH、NMP22、뇨탈락세포학적민감성분별위81．4％、86．0％、39．5％，특이성분별위84．0％、72．0％、96．0％，FISH연합NMP22검측적민감성위79．1％、특이성위92．0％。결론：FISH-NMP22연합검측유교고적민감성화특이성，기민감성원고우세포학검측，이특이성여세포학검측상차심소，연합검측교단일지표적검측대방광암구유경고적진단개치。
Objective To investigate a non-invative , sensitive and specific method to diagnose bladder cancer, and evaluate the value of the combination of FISH with NMP22 in the diagnosis of bladder cancer. Methods Urine from 68 patients suspected suffering from bladder cancer were used by FISH, NMP22 expression and cytologi-cal examination, respectively. The results of above detections were compared to the subsequent histopathology as-say to analyze the specicficity, sensitivity of diagnosis for bladder cancer. Results The sensitivity of FISH, NMP22 expression and the cytological examination was 81.4%,86.0% and 39.5% respectively, and the specifici-ty of FISH, NMP22 expression and the cytological examination was 84.0%, 72.0% and 96.0%, respectively. The sensitivity and specificity of the combination of FISH with NMP22 was 79.1% and 92.0%. Conclusions The combined diagnosis of FISH and NMP22 for bladder cancer showed greater sensitivity than that of the conventional cytology, with similar specificity as the conventional cytology. The combination of FISH with NMP22 test shows more value for the diagnosis of bladder cancer than any single assay.