CAJ | 학술논문

目的：对缺血性卒中后非流利型失语症患者的静息态功能磁共振原始数据进行比率低频振幅的处理分析，探讨其脑功能损伤及代偿的病理机制。方法：对17例失语患者（患者组）及19例年龄、性别、受教育程度均匹配的健康对照者（正常组）进行静息状态下的功能磁共振成像扫描，扫描序列为回波平面成像序列，应用DPARSF软件进行数据处理，并进行对比分析。结果：同正常组比较，患者组右侧颞上回、顶下小叶、中央后回及额叶皮层的fALFF值增高；右侧丘脑及双侧的小脑半球的fALFF值明显降低。结论：静息状态下，缺血性卒中后非流利型失语的患者在某些脑区存在异常激活，反映其脑功能失调的病理变化，为临床从大脑神经活动层面进一步了解失语症损伤及其代偿过程提供了客观依据。
목적：대결혈성졸중후비류리형실어증환자적정식태공능자공진원시수거진행비솔저빈진폭적처리분석，탐토기뇌공능손상급대상적병리궤제。방법：대17례실어환자（환자조）급19례년령、성별、수교육정도균필배적건강대조자（정상조）진행정식상태하적공능자공진성상소묘，소묘서렬위회파평면성상서렬，응용DPARSF연건진행수거처리，병진행대비분석。결과：동정상조비교，환자조우측섭상회、정하소협、중앙후회급액협피층적fALFF치증고；우측구뇌급쌍측적소뇌반구적fALFF치명현강저。결론：정식상태하，결혈성졸중후비류리형실어적환자재모사뇌구존재이상격활，반영기뇌공능실조적병리변화，위림상종대뇌신경활동층면진일보료해실어증손상급기대상과정제공료객관의거。
Objective To understand the impairment and compensation mechanism of brain function in pa-tients with non-fluent aphasia after ischemic stroke. The fractional amplitude of low frequency fluctuation (fALFF) method was used to analyze the functional magnetic resonance imaging (fMRI) data in the resting state between the aphasia patients and the normal controls. Methods The scans of the resting state of fMRI were performed in 17 aphasia patients and 19 age-, education-, and sex-matched healthy control subjects. The scan sequence was single-shot echo planar image,DPARSF software was used to analyze fALFF data of the aphasia patients and the healthy controls. Results Compared to the control group, the value in right superior temporal gurus, inferior parietal lob-ule, frontal lobe cortex, and postcentral gurus were significantly increased in the aphasia group. The fALFF in bilat-eral cerebellum and right thalamus were also decreased in the aphasia group. Conclusions The fALFF values in some brain region in the aphasia group were abnormal in the resting state , indicating a few pathological change of brain function in patients with non-fluent aphasia after ischemic stroke.