重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
11期
1329-1330,1334
,共3页
代谢综合征%尿酸%相关性分析%代谢组分
代謝綜閤徵%尿痠%相關性分析%代謝組分
대사종합정%뇨산%상관성분석%대사조분
metabolic syndrome%uric acid%correlation analysis%relationship
目的:探讨老年女性血尿酸(SUA)与代谢综合征(MS)及各代谢组分的相互关系。方法将147例年龄大于60岁的女性MS患者根据合并代谢组分的数量分为MSⅠ、Ⅱ、Ⅲ组,比较3组之间的SUA差异;采用四分位法将SUA分为4组,比较4组间代谢组分的差异。采用Logistic回归分析MS各代谢组分与SUA之间的相互关系。结果MSⅠ、Ⅱ组与MSⅢ组的SUA水平比较,差异有统计学意义(P<0.05);SUA4个区间q25(<44.31mg/L)、q50(44.31~53.24mg/L)、q75(>53.24~62.68mg/L)和q100(>62.68mg/L)患者的腰围、收缩压(SBP)、舒张压(DBP)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和空腹血糖(FPG)比较,差异均有统计学意义(P<0.05)。与SUA<44.31mg/L比较,SUA44.31~53.24、>53.24~62.68、>62.68mg/L3个区间的MS发生风险分别为1.87(95%CI1.35~2.59)、2.71(95%CI1.88~3.91)和4.88(95%CI3.12~7.63)。SUA的危险因素有腰围(OR=2.56,95%CI1.52~4.31)、TG(OR=2.21,95%CI1.63~3.00)、SBP(OR=1.68,95%CI1.33~2.12)、DBP(OR=1.84,95%CI1.41~2.40)、FPG(OR=2.16,95%CI1.68~2.78)和代谢组分合并数量(OR=2.87,95%CI1.89~4.36),SUA的保护因素有HDL-C(OR=0.48,95%CI0.29~0.79)。结论SUA和MS各组分可能存在着相互作用。
目的:探討老年女性血尿痠(SUA)與代謝綜閤徵(MS)及各代謝組分的相互關繫。方法將147例年齡大于60歲的女性MS患者根據閤併代謝組分的數量分為MSⅠ、Ⅱ、Ⅲ組,比較3組之間的SUA差異;採用四分位法將SUA分為4組,比較4組間代謝組分的差異。採用Logistic迴歸分析MS各代謝組分與SUA之間的相互關繫。結果MSⅠ、Ⅱ組與MSⅢ組的SUA水平比較,差異有統計學意義(P<0.05);SUA4箇區間q25(<44.31mg/L)、q50(44.31~53.24mg/L)、q75(>53.24~62.68mg/L)和q100(>62.68mg/L)患者的腰圍、收縮壓(SBP)、舒張壓(DBP)、三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-C)和空腹血糖(FPG)比較,差異均有統計學意義(P<0.05)。與SUA<44.31mg/L比較,SUA44.31~53.24、>53.24~62.68、>62.68mg/L3箇區間的MS髮生風險分彆為1.87(95%CI1.35~2.59)、2.71(95%CI1.88~3.91)和4.88(95%CI3.12~7.63)。SUA的危險因素有腰圍(OR=2.56,95%CI1.52~4.31)、TG(OR=2.21,95%CI1.63~3.00)、SBP(OR=1.68,95%CI1.33~2.12)、DBP(OR=1.84,95%CI1.41~2.40)、FPG(OR=2.16,95%CI1.68~2.78)和代謝組分閤併數量(OR=2.87,95%CI1.89~4.36),SUA的保護因素有HDL-C(OR=0.48,95%CI0.29~0.79)。結論SUA和MS各組分可能存在著相互作用。
목적:탐토노년녀성혈뇨산(SUA)여대사종합정(MS)급각대사조분적상호관계。방법장147례년령대우60세적녀성MS환자근거합병대사조분적수량분위MSⅠ、Ⅱ、Ⅲ조,비교3조지간적SUA차이;채용사분위법장SUA분위4조,비교4조간대사조분적차이。채용Logistic회귀분석MS각대사조분여SUA지간적상호관계。결과MSⅠ、Ⅱ조여MSⅢ조적SUA수평비교,차이유통계학의의(P<0.05);SUA4개구간q25(<44.31mg/L)、q50(44.31~53.24mg/L)、q75(>53.24~62.68mg/L)화q100(>62.68mg/L)환자적요위、수축압(SBP)、서장압(DBP)、삼선감유(TG)、고밀도지단백담고순(HDL-C)화공복혈당(FPG)비교,차이균유통계학의의(P<0.05)。여SUA<44.31mg/L비교,SUA44.31~53.24、>53.24~62.68、>62.68mg/L3개구간적MS발생풍험분별위1.87(95%CI1.35~2.59)、2.71(95%CI1.88~3.91)화4.88(95%CI3.12~7.63)。SUA적위험인소유요위(OR=2.56,95%CI1.52~4.31)、TG(OR=2.21,95%CI1.63~3.00)、SBP(OR=1.68,95%CI1.33~2.12)、DBP(OR=1.84,95%CI1.41~2.40)、FPG(OR=2.16,95%CI1.68~2.78)화대사조분합병수량(OR=2.87,95%CI1.89~4.36),SUA적보호인소유HDL-C(OR=0.48,95%CI0.29~0.79)。결론SUA화MS각조분가능존재착상호작용。
Objective To discuss the relationship between serum uric acid (SUA) and the metabolic components in metabolic syndrome(MS) .Methods 147 female cases of MS aged >60 year old were divided into MS Ⅰ group ,MSⅡ group and MS Ⅲgroup according to numbers of metabolic components ,and the levels of SUA were compared among the three groups .These patients were also subdivided into 4 groups according to the SUA levels by the quartile division ,and the differences of the metabolic compo-nents were compared among the 4 groups .The relationship between SUA and various metabolic components of MS was analyzed by Logistic regression analysis .Results The SUA level had statistical difference among the MS Ⅰ group ,MSⅡ group and MS Ⅲgroup(P<0 .05);the four SUA intervals of q25(< 44 .31 mg/L) ,q50(44 .31 -53 .24 mg/L) ,q75(>53 .24 -62 .68 mg/L) and q100(>62 .68 mg/L) showed significant differences in waistline ,SBP ,DBP ,TG ,HDL-C and FPG(P<0 .05) .Compared with the SUA interval of <44 .31 mg/L ,the occurrence risk of MS in the SUA intervals of (44 .31-53 .24) ,> (53 .24-62 .68) and >62 .68 mg/L were 1 .87(95% CI1 .35-2 .59) ,2 .71(95% CI 1 .88 -3 .91) and 4 .88(95% CI 3 .12 -7 .63) ,respectively .Waistline(OR=2 .56 ,95% CI 1 .52-4 .31) ,TG(OR=2 .21 ,95% CI 1 .63-3 .00) ,SBP(OR=1 .68 ,95% CI 1 .33-2 .12) ,DBP(OR=1 .84 ,95% CI 1 .41-2 .40) ,FPG(OR=2 .16 ,95% CI 1 .68-2 .78) and numbers of metabolic components (OR=2 .87 ,95% CI 1 .89-4 .36) were the risk factors for SUA ,and the HDL-C was the protective factor(OR=0 .48 ,95% CI 0 .29-0 .79) .Conclusion There may be in-teraction between SUA and the metabolic components of MS .