CAJ | 학술논문

目的：探讨心肌钙蛋白I（cTnI）与同型半胱氨酸（Hcy）联合检测对提高非ST段抬高心肌梗死（NSTEMI）诊疗效果的作用。方法检测47例NSTEMI患者（NSTEMI组）在治疗前、后及63例健康体检者（对照组）的cTnI和Hcy水平，并通过统计学方法验证这两项指标对于判断 NSTEMI诊疗效果的价值。结果 NSTEMI组血清cTnI为（2．37±0．65）ng/mL、Hcy为（19．23±2．94）μmol/L ，均显著高于对照组的cTnI（0．33±0．14）ng/mL、Hcy（10．62±3．27）μmol/L ，两组比较差异有统计学意义（P＜0．05）；单一cTnI与 Hcy指标检测灵敏度分别为95．74％和85．11％，特异性分别为85．71％和90．48％；两项指标联合检测的灵敏度与特异性达到97．87％和98．41％；NSTEMI组治疗后的cTnI和Hcy水平均显著下降并接近正常水平。结论 cTnI和Hcy联合检测不仅可用于NSTEMI的诊断，而且对于NSTEMI的疗效判断具有重要意义。
목적：탐토심기개단백I（cTnI）여동형반광안산（Hcy）연합검측대제고비ST단태고심기경사（NSTEMI）진료효과적작용。방법검측47례NSTEMI환자（NSTEMI조）재치료전、후급63례건강체검자（대조조）적cTnI화Hcy수평，병통과통계학방법험증저량항지표대우판단 NSTEMI진료효과적개치。결과 NSTEMI조혈청cTnI위（2．37±0．65）ng/mL、Hcy위（19．23±2．94）μmol/L ，균현저고우대조조적cTnI（0．33±0．14）ng/mL、Hcy（10．62±3．27）μmol/L ，량조비교차이유통계학의의（P＜0．05）；단일cTnI여 Hcy지표검측령민도분별위95．74％화85．11％，특이성분별위85．71％화90．48％；량항지표연합검측적령민도여특이성체도97．87％화98．41％；NSTEMI조치료후적cTnI화Hcy수평균현저하강병접근정상수평。결론 cTnI화Hcy연합검측불부가용우NSTEMI적진단，이차대우NSTEMI적료효판단구유중요의의。
Objective To discuss the effect of the combination detection of cardiac troponin I (cTnI) and homocysteine(Hcy) for increasing the diagnosis and treatment offects of non-ST elevation myocardial infarction (NSTEMI) .Methods The levels of cTnI and Hcy were detected in 47 patients with NSTEMI(NSTEMI group) before and after therapy and 63 healthy individuals(control group) .The detection results were performed the statistical analysis for verifying their value to judge the diagnostic and treatment effect of NSTEMI .Results The levels of cTnI and Hcy were (2 .37 ± 0 .65)ng/mL and(19 .23 ± 2 .94)μmol/L in the NSTEMI group ,which were significantly higher than(0 .33 ± 0 .14)ng/mL and(10 .62 ± 3 .27)μmol/L in the control group ,the differences showing statistical significance (P< 0 .05);the sensitivities of single cTnI and Hcy were 95 .74% and 85 .11% respectively ,and their specificities were 85 .71% and 90 .48% respectively ;the sensitivity and sepecificity of cTnI and Hcy combination detection were risen to 97 .87% and 98 .41% respectively ;after therapy ,the cTnI and Hcy levels in the NSTEMI group were significantly lowered and close to the normal levels .Conclusion The combination detection of cTnI and Hcy can not only be used for the diagno-sis of NSTEMI ,but also has the important significance to the judgment of the therapeutical effect of NSTEMI .