CAJ | 학술논문

目的：通过低营养亚健康小鼠模型及益损指数-累计积分（BDI-GS ）方式对市售两种中药保健品A、B胶囊的实际保健功效及安全性进行对比综合评价，并进行保健品相关问题的探讨。方法实验用生长期健康IC R雄性小鼠，通过玉米低营养饲料和0．25％、0．50％、0．75％3个剂量保健品掺和饲料喂养12 d ，记录小鼠体质量，解剖后统计9项脏器系数及其BDI、GS等指标，以及血清生化指标。结果胶囊A中、高剂量组表现一定的保健功效，而低剂量组存在轻微负面效应，体现在GS值上；胶囊B在3个剂量均对机体主要脏器组织产生不同程度的损害，体现在多脏器的系数BDI＜1．0，GS＜9．0。结论目前市售的中药保健品种组成相近，但内在质量差异较大，甚至部分产品还存在有一定不良反应，其功效及安全性并未能得到充分保障。通过BDI-GS体系评价，可提高保健品的市场准入标准，以提高保健品的功效及安全水平。
목적：통과저영양아건강소서모형급익손지수-루계적분（BDI-GS ）방식대시수량충중약보건품A、B효낭적실제보건공효급안전성진행대비종합평개，병진행보건품상관문제적탐토。방법실험용생장기건강IC R웅성소서，통과옥미저영양사료화0．25％、0．50％、0．75％3개제량보건품참화사료위양12 d ，기록소서체질량，해부후통계9항장기계수급기BDI、GS등지표，이급혈청생화지표。결과효낭A중、고제량조표현일정적보건공효，이저제량조존재경미부면효응，체현재GS치상；효낭B재3개제량균대궤체주요장기조직산생불동정도적손해，체현재다장기적계수BDI＜1．0，GS＜9．0。결론목전시수적중약보건품충조성상근，단내재질량차이교대，심지부분산품환존재유일정불량반응，기공효급안전성병미능득도충분보장。통과BDI-GS체계평개，가제고보건품적시장준입표준，이제고보건품적공효급안전수평。
Objective To conduct the comparative comprehensive evaluation on the actual healthy effects and safety of two kinds of healthy foods capsule A and B made of Chinese medicinal herbs on sale through the low-nutritional sub-health mice model com-bined with the benefit-damage index-general score(BDI-GS) approach ,and to perform the discussion on the relevant problems a-round healthy foods .Methods The experimental healthy ICR male mice during growth period were fed with maize low-nutritional feed and the mixed feed with 3 doses of 0 .25% ,0 .5% ,0 .75% healthy foods for 12 d and the mice body masses were recorded .Af-ter dissection ,9 items of the organ index and their BDI ,GS and serum biochemical indicators were performed the statistics .Results In the capsule A ,the medium and high dose groups manifested certain health-promoting effect ,while the slight negative effect exis-ted in the low dose group ,which was expressed in the GS values ;but in the capsule B ,3 doses all caused the damage to main internal organs in different degrees ,which was expressed in BDI<1 .0 and GS<9 .0 .Conclusion At present ,despite of possessing similar ingredients ,Chinese medicinal healthy foods in market are of greater differences in intrinsic qualities ,and even partial products have some adverse effect ,the healthy functions and safety are not enough to be fully ensured .Through the systematic evaluation of the BDI-GS system ,the criteria of marketing threshold for healthy foods will be increased so as to enhance their effects and safety level .