CAJ | 학술논문

原发性肝癌是世界范围内常见的恶性肿瘤之一，目前对中晚期肝癌尚无特别有效的治疗措施。华蟾素是我国传统中药材中华大蟾蜍阴干皮经提取加工制成的灭菌水溶液，具有清热解毒、利水消胀、化瘀软坚、消肿止痛等功效，是我国应用较为广泛的一类抗肿瘤中药制剂。临床研究表明，华蟾素对乙型肝炎有一定的抑制作用，可有效地抑制原发性肝癌的发生。同时，利用华蟾素单纯静脉滴注、静脉滴注联合其他药物、静脉滴注联合肝动脉化疗栓塞、肝动脉化疗栓塞治疗及肝内注射等治疗方法，对中晚期肝癌患者也具有较好的疗效。本文对近年来华蟾素预防和治疗原发性肝癌的临床疗效进行综述。
원발성간암시세계범위내상견적악성종류지일，목전대중만기간암상무특별유효적치료조시。화섬소시아국전통중약재중화대섬서음간피경제취가공제성적멸균수용액，구유청열해독、이수소창、화어연견、소종지통등공효，시아국응용교위엄범적일류항종류중약제제。림상연구표명，화섬소대을형간염유일정적억제작용，가유효지억제원발성간암적발생。동시，이용화섬소단순정맥적주、정맥적주연합기타약물、정맥적주연합간동맥화료전새、간동맥화료전새치료급간내주사등치료방법，대중만기간암환자야구유교호적료효。본문대근년래화섬소예방화치료원발성간암적림상료효진행종술。
Hepatocellular carcinoma ( HCC) is one of the most common malignant neoplasms worldwide , and remains a formidable challenge for clinical therapy.The skin of Bufo bufo gargarizans Cantor has been reported to have antipyretic , detoxicant, diuresis, stasis-eliminative , and pus-discharging properties.Cinobufacini ( Huachansu ) , an aqueous extract of dried skin of B.bufo gargarizans B.bufo gargarizans Cantor , is a traditional Chinese medicinal preparation widely used in clinical cancer therapy in China .In recent years , atten-tions have been paid to cinobufacini for the treatment of HCC.These clinical data have demonstrated that cinobufacini is effective against HCC through intravenous drip , drug combination , or other methods.Moreover , cinobufacini is a promising candidate for the treatment of hepatitis B or hepatic fibrosis to prevent the development of HCC.The present review focuses on clinical researches about cinobufacini for prevention and treatment of HCC in recent years.