CAJ | 학술논문

目的：为了筛选出防治猪呼吸道疾病综合征（ PRDC）有效的中药复方制剂，对七个具有止咳化痰作用的中药复方制剂进行了对比实验。方法以小鼠为实验动物，用右美沙芬、氯化铵作阳性药，生理盐水作空白对照，采用浓氨水引咳法和气管段酚红分泌法，对七个中药复方制剂的止咳化痰作用进行了观测。结果方7、方5可显著延长小鼠的咳嗽潜伏期（P＜0.05），减少5 min内的咳嗽次数（P＜0.05），除方4组外，其他中药组的气管酚红排泌量显著低于对照组（ P ＜0.05），并且方7、方5和氯化铵组小鼠的酚红排泌量显著低于其他处理组（ P＜0.05）。结论七个中药复方组中，方5、方7的止咳化痰作用最显著，可在进一步实验研究后，作为PRDC的治疗药物。
목적：위료사선출방치저호흡도질병종합정（ PRDC）유효적중약복방제제，대칠개구유지해화담작용적중약복방제제진행료대비실험。방법이소서위실험동물，용우미사분、록화안작양성약，생리염수작공백대조，채용농안수인해법화기관단분홍분비법，대칠개중약복방제제적지해화담작용진행료관측。결과방7、방5가현저연장소서적해수잠복기（P＜0.05），감소5 min내적해수차수（P＜0.05），제방4조외，기타중약조적기관분홍배비량현저저우대조조（ P ＜0.05），병차방7、방5화록화안조소서적분홍배비량현저저우기타처리조（ P＜0.05）。결론칠개중약복방조중，방5、방7적지해화담작용최현저，가재진일보실험연구후，작위PRDC적치료약물。
Objective In order to screen effective traditional Chinese medicine compounds to prevent and control porcine respiratory disease syndrome ( PRDC) , seven compound preparations of traditional Chinese medicine were tested and to analyze their antitussive and expectorant effects in mice .Methods Two hundred 6-week old ICR mice ( male∶fe-male=1∶1) were used in this study .Dextromethorphan and ammonium chloride were used as positive control drugs , and physiological saline was used as blank control .The antitussive and expectorant effects of the seven Chinese medicine com-pounds (groups 1, 2, 3, 4, 5, 6, 7) were observed by ammonia-induced cough model and tracheal phenol red secretion method in mice .Results The results showed that compounds 7 and 5 significantly prolonged the cough incubation period (P <0.05), and reduced the cough times within 5 min (P <0.05).Except for the group 4, tracheal phenol red excre-tion in the other groups was significantly lower than that of blank control group (P <0.05), and phenol red excretion in the mice of groups 7, 5 and ammonium chloride group was significantly lower than that in other treatment groups ( P <0.05).Conclusions The Chinese medicine compounds 5 and 7 show most evident expectorant effects , and worthy of fur-ther validation of them as a drug in the treatment of porcine respiratory disease syndrome .