CAJ | 학술논문

目的探讨存活素 Survivin和增殖细胞核抗原 Ki-67在肾癌中的表达及两者之间的关系。方法应用免疫组织化学法检测60例肾癌组织和20例癌旁正常肾组织中 Survivin 和Ki-67的表达水平,并对60例肾癌患者的临床及病理资料进行回顾性分析。结果Survivin在肾癌组织中的表达率为66.7%,在癌旁组织中不表达,两者差异有统计学意义(P<0.05),Survivin在肾癌中的表达与肾癌病理分级、临床分期、淋巴结转移均显著相关(P<0.05)。Ki-67在肾癌组织中的表达率为61.7%,在癌旁组织中的表达率为10.0%,两者差异有统计学意义(P<0.05),Ki-67在肾癌中的表达与病理分级、临床分期、淋巴结转移均显著相关(P<0.05)。Survivin和 Ki-67在肾癌组织中均异常高表达,两者表达呈正相关(P<0.001)。结论Survivin和 Ki-67在肾癌的发生发展中起重要作用,联合检测两指标可为肾癌预后提供重要依据。
목적탐토존활소 Survivin화증식세포핵항원 Ki-67재신암중적표체급량자지간적관계。방법응용면역조직화학법검측60례신암조직화20례암방정상신조직중 Survivin 화Ki-67적표체수평,병대60례신암환자적림상급병리자료진행회고성분석。결과Survivin재신암조직중적표체솔위66.7%,재암방조직중불표체,량자차이유통계학의의(P<0.05),Survivin재신암중적표체여신암병리분급、림상분기、림파결전이균현저상관(P<0.05)。Ki-67재신암조직중적표체솔위61.7%,재암방조직중적표체솔위10.0%,량자차이유통계학의의(P<0.05),Ki-67재신암중적표체여병리분급、림상분기、림파결전이균현저상관(P<0.05)。Survivin화 Ki-67재신암조직중균이상고표체,량자표체정정상관(P<0.001)。결론Survivin화 Ki-67재신암적발생발전중기중요작용,연합검측량지표가위신암예후제공중요의거。
Objective To study the expression of Survivin and Ki-67 in renal cell carcinoma (RCC)tissues,and to investigate the relationship between them. Methods Immunohistochemical staining was used to detect the expression of Survivin and Ki-67 in 60 cases of renal cell carcinoma tissues and 20 cases of adjacent tissues.Furthermore,the clinical and pathological data of 60 cases of RCC were retrospectively analyzed. Results The positive expression rate of Survivin was 66.7%and 0% in RCC and the adjacent tissues respectively.There was significant difference between the two groups (P<0.05).The expression of Survivin in RCC was significantly related with histologic grade,clinical stage and lymph node metastasis (P<0.05).The positive expression rate of Ki-67 was 61.7% and 10.0% in RCC and the adjacent tissues respectively.There was significant difference between the two groups (P<0.05).The expression of Ki-67 in RCC was significantly related with histologic grade,clinical stage and lymph node metastasis (P<0.05).The expression of Survivin and Ki-67are highly expressed in RCC,and the expression of Survivin has a positive correlation with Ki-67 (P<0.001). Conclusions Survivin and Ki-67 may play an important role in the develop-ment of RCC.Combined detection of both can provide an important basis for the prognosis of RCC.