CAJ | 학술논문

微波辐射下利用3-甲氧基-2-羟基苯甲醛和丙二酸二甲酯在甲醇溶剂中反应，高产率地合成了8-甲氧基香豆素-3-甲酸甲酯，通过元素分析、IR、1 HNMR和X-射线单晶衍射分析确定了其结构．该化合物属单斜晶系，P21/c空间群，a＝0．40283（14）nm，b＝2．4867（8）nm，c＝1．0379（4）nm，β＝93．272（4）°，Z＝4，V＝1．0380（6） nm3，R1＝0．0560，wR2＝0．1532．化合物是一平面分子，分子间通过弱的 C-H…O氢键和π-π堆积作用形成了三维超分子结构．用微量热法研究了该化合物对大肠杆菌生长的抑制作用，结果表明该化合物有较好的抑菌活性．
미파복사하이용3-갑양기-2-간기분갑철화병이산이갑지재갑순용제중반응，고산솔지합성료8-갑양기향두소-3-갑산갑지，통과원소분석、IR、1 HNMR화X-사선단정연사분석학정료기결구．해화합물속단사정계，P21/c공간군，a＝0．40283（14）nm，b＝2．4867（8）nm，c＝1．0379（4）nm，β＝93．272（4）°，Z＝4，V＝1．0380（6） nm3，R1＝0．0560，wR2＝0．1532．화합물시일평면분자，분자간통과약적 C-H…O경건화π-π퇴적작용형성료삼유초분자결구．용미량열법연구료해화합물대대장간균생장적억제작용，결과표명해화합물유교호적억균활성．
Under microwave irradiation,methyl 8-methoxycoumarin-3-carboxylate is synthesized by the con-densation reaction of 3-methoxy-2-hydroxybenzaldehyde and dimethyl malonate in methanol with good yield,and then the structur is characterized by elemental analysis,IR,1 HNMR and X-ray single crystal diffraction.The crys-tal belongs to monoclinic space group P21/c with a=0.40283(14)nm,b=2.4867(8)nm,c=1.0379(4)nm,β=93.272(4)°,Z=4,V=1.0380(6)nm3 ,R1=0.0560,wR2=0.1532.The compound is a planar molecule,and a three-dimension supramolecular structure is formed by the intermolecular C-H…O hydrogen bonds andπ-πstacking interactions.The inhibition of the compound on the growth of E.coli has been studied by the microcalori-metric method,and the result shows that the compound possesses good anti-bacterial activity.