CAJ | 학술논문

以淀粉和氧氟沙星为原料，合成了淀粉支载的氧氟沙星高分子前药，用核磁共振氢谱对其结构进行了结构表征、紫外分光光度计测定了氧氟沙星的接入率，并在人工胃液和人工肠液中进行了体外释放研究。结果清楚显示氧氟沙星成功接入到淀粉分子上，该高分子前药在不同介质的体外释放中均呈现零级缓慢释药，与氧氟沙星相比较，其作用时间明显增长，可以有效减缓药物成分的释放，控制血药浓度，有望大大减轻药物对胃粘膜和肠的刺激作用，并解决氧氟沙星的味苦及难溶等问题。
이정분화양불사성위원료，합성료정분지재적양불사성고분자전약，용핵자공진경보대기결구진행료결구표정、자외분광광도계측정료양불사성적접입솔，병재인공위액화인공장액중진행료체외석방연구。결과청초현시양불사성성공접입도정분분자상，해고분자전약재불동개질적체외석방중균정현령급완만석약，여양불사성상비교，기작용시간명현증장，가이유효감완약물성분적석방，공제혈약농도，유망대대감경약물대위점막화장적자격작용，병해결양불사성적미고급난용등문제。
In order to obtain a sustained-release nicotinic acid ,starch-nicotinic acid conjugation was syn-thesized by coupling between starch and nicotinyl chloride .Its structure was characterized with FTIR and 1H-NMR.The drug-loading ratio of the product was measured by ultraviolet spectrophotometer .And in vitro drug release investigation was carried out in artificial gastric juice and artificial intestinal juice .The results clearly showed that nicotinic acid was coupled with the starch molecule successfully and the drug release rate of the conjugatation was nearly zero order without abrupt release .Compared with nicotinic acid , the effective thera-peutic time of the polymer prodrug was prolonged .So it may lead to less side-effect and relieving stimulation on gastrointestinal tract .