CAJ | 학술논문

目的：了解恶性肿瘤接受化疗患者合并医院内获得性感染的发病特点，指导临床有效防治。方法回顾性分析295例院内感染的恶性肿瘤化疗患者的临床资料。结果3 a 内院内感染率分别为7.04%、6.01%和5.78%，呈逐年下降趋势；院内感染与年龄、性别、住院时间、糖皮质激素的使用、白细胞减少有关（P <0.05），感染病原菌以真菌及革兰氏阴性菌居多。结论恶性肿瘤患者合并院内感染的发生率较高，积极采取预防措施，减少易感因素，合理使用抗生素是关键。
목적：료해악성종류접수화료환자합병의원내획득성감염적발병특점，지도림상유효방치。방법회고성분석295례원내감염적악성종류화료환자적림상자료。결과3 a 내원내감염솔분별위7.04%、6.01%화5.78%，정축년하강추세；원내감염여년령、성별、주원시간、당피질격소적사용、백세포감소유관（P <0.05），감염병원균이진균급혁란씨음성균거다。결론악성종류환자합병원내감염적발생솔교고，적겁채취예방조시，감소역감인소，합리사용항생소시관건。
Objective To study the characteristics of hospital acquired infections in patients with cancer treated by chemotherapy,and to provide the guidance for clinical prevention and treatments. Methods The clinical data of 295 cases of hospital acquired infections in patients with cancer treated by chemotherapy were analyzed retrospec-tively. Results In the recent three years,the incidences of hospital acquired infections were 7. 04% ,6. 01% and 5. 78% ,respectively. The trend was decreasing year by year. Hospital acquired infections were related with age,gen-der,length of hospitalization,use of glucocorticoid,leucopenia(P < 0. 05). The pathogens were mainly fungi and Gram negative bacteria. Conclusion There is a relatively higher incidence of hospital acquired infections in pa-tients with cancer and the key points of prevention lie in reducing the predisposing factors,rational use of antibiotics and taking actively prophylactic measures.