CAJ | 학술논문

目的：分析突变型 Ras 蛋白表达与食管癌复发的相关性。方法采用免疫组化 S-P 法检测65例食管癌（复发组43例和未复发组22例）手术标本中突变型 Ras 蛋白的表达情况。结果复发组 Ras 蛋白阳性表达率是72.09%（31/43），未复发组是18.18%（4/22）（P <0.05），且其表达与分化程度有关。结论突变型 Ras 蛋白检测可作为预测食管癌术后是否复发的参考因素。
목적：분석돌변형 Ras 단백표체여식관암복발적상관성。방법채용면역조화 S-P 법검측65례식관암（복발조43례화미복발조22례）수술표본중돌변형 Ras 단백적표체정황。결과복발조 Ras 단백양성표체솔시72.09%（31/43），미복발조시18.18%（4/22）（P <0.05），차기표체여분화정도유관。결론돌변형 Ras 단백검측가작위예측식관암술후시부복발적삼고인소。
Objective To investigate the correlation of Ras protein with recurrence in esophagus carcinoma. Methods Immunohistochemistry S-P method was used to detect the mutated Ras protein expression in the 65 pa-tients with undergone surgery for esophagus carcinoma(43 patients with recurrence and 22 patients without recur-rence). Results The positive rate of mutated Ras protein was 72. 09%(31 / 43)in the patients with recurrence, and was 18. 18%(4 / 22)in the patients without recurrence(P < 0. 05). The expression of mutated Ras protein was related to differentiation. Conclusion Mutated Ras protein may be refered as a factor for predicting the recurrence in esophagus carcinoma.