CAJ | 학술논문

采用单乳化溶剂挥发法制备负载MMC的PLGA微球,通过相分离与冷冻干燥,制备含有载药微球的明胶多孔支架。支架的孔隙率达到90.2%,溶胀率为22.7%,压缩模量为52.1 kPa。体外释放实验表明,载药微球中,MMC在5周的累计释放量为77.3%；支架中 MMC 的释放相对较缓,5周累积释放量为65.2%。这种含有载药微球的明胶复合多孔支架具有潜在的抗瘢痕应用前景。
채용단유화용제휘발법제비부재MMC적PLGA미구,통과상분리여냉동간조,제비함유재약미구적명효다공지가。지가적공극솔체도90.2%,용창솔위22.7%,압축모량위52.1 kPa。체외석방실험표명,재약미구중,MMC재5주적루계석방량위77.3%；지가중 MMC 적석방상대교완,5주루적석방량위65.2%。저충함유재약미구적명효복합다공지가구유잠재적항반흔응용전경。
Employing PLGA as carriers,Mitomycin C( MMC) loaded microspheres were fabricated by oil-in-wa-ter single emulsion solvent evaporation technique. PLGA/MMC microspheres were embedded into gelatin porous scaffold via freeze drying method. The porosity,swelling ratio and compressive modulus of scaffold were 90.2%, 22.7% and 52.1kPa,respectively. The cumulative released of MMC in scaffold was 65.2% in 5 weeks. This MMC loaded gelatin scaffold has the potential application in antiscaring.