现代仪器与医疗
現代儀器與醫療
현대의기여의료
Modern Instrument and Medical Treatment
2014年
3期
11-13
,共3页
顺式阿曲库铵%剂量%神经肌肉阻滞%小儿
順式阿麯庫銨%劑量%神經肌肉阻滯%小兒
순식아곡고안%제량%신경기육조체%소인
cisatracurium%doses%neuromuscular blockade%children
目的：比较不同剂量顺式阿曲库铵在小儿外科手术中的肌松作用，探讨其临床使用中最适剂量。方法：48位患儿随机分为3组，分别应用2倍ED95，3倍ED95和4倍ED95的顺式阿曲库铵进行随机对照研究，观察3组患儿肌松药起效时间、有效作用时间、插管条件、血流动力学等指标。结果：3组间注射顺式阿曲库铵前及注射1～5m i n后心率、平均动脉压差异无统计学意义。高剂量组（3倍E D95和4倍E D95）顺式阿曲库铵起效时间、有效作用时间、体内作用时间均短于和久于2倍E D95剂量组，差异有统计学意义。3组间恢复指数差异无统计学意义。高剂量组能获得较好的插管条件，与低剂量组比较差异具有统计学意义。但3倍E D95和4倍E D95剂量组在起效时间、插管条件等方面差异无统计学意义。结论：小儿应用3倍E D95和4倍E D95顺式阿曲库铵有着更快速的神经肌松作用，且持续时间更长、血流动力学更稳定。3倍ED95为最合适的诱导剂量。
目的：比較不同劑量順式阿麯庫銨在小兒外科手術中的肌鬆作用，探討其臨床使用中最適劑量。方法：48位患兒隨機分為3組，分彆應用2倍ED95，3倍ED95和4倍ED95的順式阿麯庫銨進行隨機對照研究，觀察3組患兒肌鬆藥起效時間、有效作用時間、插管條件、血流動力學等指標。結果：3組間註射順式阿麯庫銨前及註射1～5m i n後心率、平均動脈壓差異無統計學意義。高劑量組（3倍E D95和4倍E D95）順式阿麯庫銨起效時間、有效作用時間、體內作用時間均短于和久于2倍E D95劑量組，差異有統計學意義。3組間恢複指數差異無統計學意義。高劑量組能穫得較好的插管條件，與低劑量組比較差異具有統計學意義。但3倍E D95和4倍E D95劑量組在起效時間、插管條件等方麵差異無統計學意義。結論：小兒應用3倍E D95和4倍E D95順式阿麯庫銨有著更快速的神經肌鬆作用，且持續時間更長、血流動力學更穩定。3倍ED95為最閤適的誘導劑量。
목적：비교불동제량순식아곡고안재소인외과수술중적기송작용，탐토기림상사용중최괄제량。방법：48위환인수궤분위3조，분별응용2배ED95，3배ED95화4배ED95적순식아곡고안진행수궤대조연구，관찰3조환인기송약기효시간、유효작용시간、삽관조건、혈류동역학등지표。결과：3조간주사순식아곡고안전급주사1～5m i n후심솔、평균동맥압차이무통계학의의。고제량조（3배E D95화4배E D95）순식아곡고안기효시간、유효작용시간、체내작용시간균단우화구우2배E D95제량조，차이유통계학의의。3조간회복지수차이무통계학의의。고제량조능획득교호적삽관조건，여저제량조비교차이구유통계학의의。단3배E D95화4배E D95제량조재기효시간、삽관조건등방면차이무통계학의의。결론：소인응용3배E D95화4배E D95순식아곡고안유착경쾌속적신경기송작용，차지속시간경장、혈류동역학경은정。3배ED95위최합괄적유도제량。
Objective: To investigate the most proper dose of cisatracurium by comparing the neuromuscular blockade of children under cisatracurium anesthesia.Method: The study was designed as a randomized controlled clinical trial including 48 children divided into 3 groups. The onset time, effective duration, intubating condition and hemodynamic change were observed.Result: There is no statistically signiifcant difference between heart rate and mean average blood pressure of children of 3 groups before or 1-5 minutes after the injection of cisatracurium. Higher doses of cisatracurium (3×ED95 and 4×ED95) showed onset time and effective duration were statistically signiifcant lower and longer than lower dose of cisatracurium (2×ED95) respectively. At the same time, higher dose of cisatracurium had a better intubating condition than lower dose of cisatracurium, statistically. But no statistically signiifcant difference was observed on onset time, intubating condition and so on between 3×ED95 and 4×ED95 dose of cisatracurium.Conclusion: The usage of 3×ED95 and 4×ED95 dose of cisatracurium provide a more effective and rapidly neuromuscular blockade in children with longer duration and hemodynamic hemostasis. 3×ED95 dose of cisatracurium is recommended as the initial dose.
