西北药学杂志
西北藥學雜誌
서북약학잡지
2014年
3期
324-328
,共5页
程涛%宋霞%马园园%姜远英%曹永兵
程濤%宋霞%馬園園%薑遠英%曹永兵
정도%송하%마완완%강원영%조영병
中药%多药耐药逆转%P-糖蛋白%多药耐药结合蛋白1%乳腺癌耐药蛋白
中藥%多藥耐藥逆轉%P-糖蛋白%多藥耐藥結閤蛋白1%乳腺癌耐藥蛋白
중약%다약내약역전%P-당단백%다약내약결합단백1%유선암내약단백
traditional Chinese medicine%multidrug resistance(MDR) reversal%P-glycoprotein(P-gp)%multidrug resistance protein 1(MRP1)%breast cancer resistance protein(BCRP)
目的:综述逆转肿瘤多药耐药(MDR)的研究进展。方法检索中药提取物或中药单体联合化疗药物逆转肿瘤MDR的研究。结果一些中药提取物或中药单体能使耐药株对化疗药物变得敏感,使耐药蛋白的转运活性下降。结论中药具有逆转肿瘤MDR的活性,其作用机制大多是与耐药相关蛋白相关的。
目的:綜述逆轉腫瘤多藥耐藥(MDR)的研究進展。方法檢索中藥提取物或中藥單體聯閤化療藥物逆轉腫瘤MDR的研究。結果一些中藥提取物或中藥單體能使耐藥株對化療藥物變得敏感,使耐藥蛋白的轉運活性下降。結論中藥具有逆轉腫瘤MDR的活性,其作用機製大多是與耐藥相關蛋白相關的。
목적:종술역전종류다약내약(MDR)적연구진전。방법검색중약제취물혹중약단체연합화료약물역전종류MDR적연구。결과일사중약제취물혹중약단체능사내약주대화료약물변득민감,사내약단백적전운활성하강。결론중약구유역전종류MDR적활성,기작용궤제대다시여내약상관단백상관적。
Objective To review the research advance about the reversal of multidrug resistance (MDR) .Methods Herbal extracts and traditional Chinese medicine combined with chemotherapy drugs to reverse MDR were analyzed .Results Some herbal extracts or traditional Chinese medicine can improve the MDR strains sensitivity to chemotherapy ,and decrease the resistance protein trans-porter activity .Conclusion Some Chinese medicine has a reversing MDR tumor activity ,and its mechanism is mostly associated with the multidrug resistance-associated protein .