CAJ | 학술논문

目的：观察祖卡木颗粒对SD大鼠体质量及主要脏器的影响。方法 SD大鼠120只，雌雄各半，按体质量随机分为对照组及低、中、高剂量药物组，剂量分别为0．7，1．4，2．8g·kg -1·d-1，po，qd，连续给药1个月，对照组给予羧甲基纤维素钠。结果与对照组比较，低、中、高剂量组的大鼠体质量、脏器质量和脏器系数无统计学差异，组织病理学检查无明显变化。结论祖卡木颗粒长期给药，对SD大鼠的体质量、脏器质量、脏器系数无影响，主要脏器组织病理学检查无明显变化。
목적：관찰조잡목과립대SD대서체질량급주요장기적영향。방법 SD대서120지，자웅각반，안체질량수궤분위대조조급저、중、고제량약물조，제량분별위0．7，1．4，2．8g·kg -1·d-1，po，qd，련속급약1개월，대조조급여최갑기섬유소납。결과여대조조비교，저、중、고제량조적대서체질량、장기질량화장기계수무통계학차이，조직병이학검사무명현변화。결론조잡목과립장기급약，대SD대서적체질량、장기질량、장기계수무영향，주요장기조직병이학검사무명현변화。
Objective To investigate the effect of Zukamu Granules ,an uyghur medicine ,on body weight and cardinal visceral organs of rats .Methods SD rats were randomly divided into low ,middle and high dose groups ,which were treated with Zukamu Granules (0.7 ,1 .4 ,2 .8 g · kg -1 · d-1 ) by oral administration ,respectively ,once a day for one month successively .The rats blank control were treated with carboxymethyl cellulose sodium .For each group ,30 rats were killed 24 h after the last treatment ,and 10 rats were killed two weeks after the treatment withdrawal .The body weight ,organ weight ,organ coefficient ,and organ histopathology of the rats in each group were systematically examined .Results Compared with the blank control ,there was no significant change in body weight ,organ weight ,organ coefficient and organ histopathology of the high dose group .Conclusion Oral administration of Zukamu Granules for one consecutive month did not affect the body weight ,organ weight ,organ coefficient and histopathology of SD rats .