中国感染控制杂志
中國感染控製雜誌
중국감염공제잡지
CHINESE JOURNAL OF INFECTION CONTROL
2014年
4期
246-248
,共3页
铜绿假单胞菌%抗菌药物%抗药性,微生物%耐药%医院感染%合理用药
銅綠假單胞菌%抗菌藥物%抗藥性,微生物%耐藥%醫院感染%閤理用藥
동록가단포균%항균약물%항약성,미생물%내약%의원감염%합리용약
Pseudomonasaeruginosa%antimicrobial agent%drug resistance,microbial%drug resistance%health-care-associated infection%rational drug use
目的:了解近年某县级医院铜绿假单胞菌的分布及耐药特点,为临床合理用药提供依据,并有助于医院感染预防与控制。方法对该院2010-2012年临床各类标本分离的铜绿假单胞菌的资料进行统计分析。结果3年共分离铜绿假单胞菌369株,主要检出自痰液及咽拭子(234株,63.41%)、尿液(41株,11.11%)和伤口拭子(28株,7.59%)标本;在病区,主要分布于重症监护室(146株,39.56%)、呼吸内科(51株,13.82%)和神经外科(37株,10.03%)。铜绿假单胞菌对多粘菌素B无耐药;对亚胺培南、美罗培南、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦和阿米卡星的耐药率较低(6.81%~22.73%);各年度相比,除多粘菌素B外,对其他抗菌药物的耐药率均有不同程度上升,部分抗菌药物具统计学意义(P<0.05)。结论该院铜绿假单胞菌主要分离自呼吸道标本,以收治危重症患者的科室分布较多;对多种抗菌药物具有较高的耐药性,且有上升趋势,临床应加强监控。
目的:瞭解近年某縣級醫院銅綠假單胞菌的分佈及耐藥特點,為臨床閤理用藥提供依據,併有助于醫院感染預防與控製。方法對該院2010-2012年臨床各類標本分離的銅綠假單胞菌的資料進行統計分析。結果3年共分離銅綠假單胞菌369株,主要檢齣自痰液及嚥拭子(234株,63.41%)、尿液(41株,11.11%)和傷口拭子(28株,7.59%)標本;在病區,主要分佈于重癥鑑護室(146株,39.56%)、呼吸內科(51株,13.82%)和神經外科(37株,10.03%)。銅綠假單胞菌對多粘菌素B無耐藥;對亞胺培南、美囉培南、頭孢哌酮/舒巴坦、哌拉西林/他唑巴坦和阿米卡星的耐藥率較低(6.81%~22.73%);各年度相比,除多粘菌素B外,對其他抗菌藥物的耐藥率均有不同程度上升,部分抗菌藥物具統計學意義(P<0.05)。結論該院銅綠假單胞菌主要分離自呼吸道標本,以收治危重癥患者的科室分佈較多;對多種抗菌藥物具有較高的耐藥性,且有上升趨勢,臨床應加彊鑑控。
목적:료해근년모현급의원동록가단포균적분포급내약특점,위림상합리용약제공의거,병유조우의원감염예방여공제。방법대해원2010-2012년림상각류표본분리적동록가단포균적자료진행통계분석。결과3년공분리동록가단포균369주,주요검출자담액급인식자(234주,63.41%)、뇨액(41주,11.11%)화상구식자(28주,7.59%)표본;재병구,주요분포우중증감호실(146주,39.56%)、호흡내과(51주,13.82%)화신경외과(37주,10.03%)。동록가단포균대다점균소B무내약;대아알배남、미라배남、두포고동/서파탄、고랍서림/타서파탄화아미잡성적내약솔교저(6.81%~22.73%);각년도상비,제다점균소B외,대기타항균약물적내약솔균유불동정도상승,부분항균약물구통계학의의(P<0.05)。결론해원동록가단포균주요분리자호흡도표본,이수치위중증환자적과실분포교다;대다충항균약물구유교고적내약성,차유상승추세,림상응가강감공。
Objective To analyze the distribution and antimicrobial resistance of Pseudomonasaeruginosa(P. aeruginosa)in a county-level hospital,provide reference for rational antimicrobial use,and promote the control and prevention of healthcare-associated infection (HAI).Methods Data of P.aeruginosaisolated from patients in a hospital between 2010 and 2012 were analyzed statistically.Results A total of 369 P.aeruginosaisolates were iso-lated,strains were mainly from specimens of sputum(n= 234,63.41% ),urine(n= 41,11.11% )and wound(n= 28, 7.59% );most strains were from intensive care unit(n= 146,39.56% ),respiratory diseases department(n= 51, 13.82% )and neurosurgical department(n= 37,10.03% ).P.aeruginosastrains were not resistant to polymyxin B;the resistance rates to imipenem,meropenem,cefoperazone/sulbactam,piperacillin/tazobactam and amikacin were all low(6.81% -22.73% );from 2010 to 2012,resistance rates to antimicrobial agents (except polymyxin B) increased with varying degrees,some antimicrobial agents showed statistical difference(P<0.05).Conclusion P. aeruginosais mainly isolated from respiratory specimens,mainly distributed in departments with serious patients;and resistance to most antimicrobial agents is high,resistance tendency is increasing,surveillance should be intensi-fied.