继续医学教育
繼續醫學教育
계속의학교육
CONTINUING MEDICAL EDUCATION
2014年
4期
39-41
,共3页
买尔旦·赛力木%金钟%阿里旦·艾尔肯%何铁汉
買爾旦·賽力木%金鐘%阿裏旦·艾爾肯%何鐵漢
매이단·새력목%금종%아리단·애이긍%하철한
胃肠道间质瘤%临床病理特征%预后
胃腸道間質瘤%臨床病理特徵%預後
위장도간질류%림상병리특정%예후
GIST%Clinicopathological features%Prognosis
目的:探讨分析胃肠道间质瘤的临床病理特征及预后相关因素。方法2010年10月~2013年10月在本院手术切除并病理证实的148例胃肠道间质瘤患者作为研究对象,收集患者血便率,腹痛率,腹胀率,结节数,瘤体直径,CD34、CD117、SMA、S-100阳性率,以及性别、年龄、肿瘤性质等资料并做统计分析。结果148例GIST患者中血便72例(48.65%),腹痛65例(43.92%),腹胀62例(41.89%)。单发肿瘤者占69.59%(103/148),多发者30.41%(45/148),CD117、CD34、SMA、S-100阳性率分别为91.22%(135/148),52.70%(78/148),36.49%(54/148),25.68%(38/148)。性别、肿瘤直径、临床症状以及免疫组化染色结果均对胃肠道间质瘤预后无影响(P>0.05),年龄和肿瘤性质是影响胃肠道间质瘤预后的因素,年龄越大,肿瘤恶性程度越高,预后越差(P<0.05)。结论胃肠道间质瘤患者常有腹痛、血便、腹胀等症状,肿瘤多为单发结节,CD117和CD34呈弥漫性阳性表达,SMA和S-100主要呈局灶性分布,年龄大和肿瘤恶性程度较高的患者预后较差,而性别、肿瘤直径、临床症状、免疫组化染色并不影响GISTs的预后。因此,临床上遇到因腹痛、血便、腹胀等症状而就诊的患者应引起足够的重视,并及早发现,及早治疗。
目的:探討分析胃腸道間質瘤的臨床病理特徵及預後相關因素。方法2010年10月~2013年10月在本院手術切除併病理證實的148例胃腸道間質瘤患者作為研究對象,收集患者血便率,腹痛率,腹脹率,結節數,瘤體直徑,CD34、CD117、SMA、S-100暘性率,以及性彆、年齡、腫瘤性質等資料併做統計分析。結果148例GIST患者中血便72例(48.65%),腹痛65例(43.92%),腹脹62例(41.89%)。單髮腫瘤者佔69.59%(103/148),多髮者30.41%(45/148),CD117、CD34、SMA、S-100暘性率分彆為91.22%(135/148),52.70%(78/148),36.49%(54/148),25.68%(38/148)。性彆、腫瘤直徑、臨床癥狀以及免疫組化染色結果均對胃腸道間質瘤預後無影響(P>0.05),年齡和腫瘤性質是影響胃腸道間質瘤預後的因素,年齡越大,腫瘤噁性程度越高,預後越差(P<0.05)。結論胃腸道間質瘤患者常有腹痛、血便、腹脹等癥狀,腫瘤多為單髮結節,CD117和CD34呈瀰漫性暘性錶達,SMA和S-100主要呈跼竈性分佈,年齡大和腫瘤噁性程度較高的患者預後較差,而性彆、腫瘤直徑、臨床癥狀、免疫組化染色併不影響GISTs的預後。因此,臨床上遇到因腹痛、血便、腹脹等癥狀而就診的患者應引起足夠的重視,併及早髮現,及早治療。
목적:탐토분석위장도간질류적림상병리특정급예후상관인소。방법2010년10월~2013년10월재본원수술절제병병리증실적148례위장도간질류환자작위연구대상,수집환자혈편솔,복통솔,복창솔,결절수,류체직경,CD34、CD117、SMA、S-100양성솔,이급성별、년령、종류성질등자료병주통계분석。결과148례GIST환자중혈편72례(48.65%),복통65례(43.92%),복창62례(41.89%)。단발종류자점69.59%(103/148),다발자30.41%(45/148),CD117、CD34、SMA、S-100양성솔분별위91.22%(135/148),52.70%(78/148),36.49%(54/148),25.68%(38/148)。성별、종류직경、림상증상이급면역조화염색결과균대위장도간질류예후무영향(P>0.05),년령화종류성질시영향위장도간질류예후적인소,년령월대,종류악성정도월고,예후월차(P<0.05)。결론위장도간질류환자상유복통、혈편、복창등증상,종류다위단발결절,CD117화CD34정미만성양성표체,SMA화S-100주요정국조성분포,년령대화종류악성정도교고적환자예후교차,이성별、종류직경、림상증상、면역조화염색병불영향GISTs적예후。인차,림상상우도인복통、혈편、복창등증상이취진적환자응인기족구적중시,병급조발현,급조치료。
Objective To investigate and analyze the clinicopathological features and prognostic factors of gastrointestinal stromal tumors. Methods 148 cases of gastrointestinal stromal tumor patients in our hospital from October 2010 to October 2013 were collected as research subjects. the bloody diarrhea rate, abdominal pain rate , bloating rate, nodules, tumors diameter, CD34, CD117, SMA, S-100-positive rate, as well as data of gender, age, tumor nature were selected and made statistical analysis. Results The rate of bloody diarrhea, abdominal pain, abdominal distension, single tumor were 48.65% (72/148), 43.92% (65/148), 41.89% (62/148), 69.59% ( 103/148 ), mainly by 30.41%(45/148), CD117, CD34, SMA, S-100 positive rates were 91.22%( 135/148 ) , 52.70%( 78/148 ) , 36.49%(54/148 ), 25.68%(38/148 ) . Gender, tumor size, clinical symptoms and results of immune histo chemical staining were no gastrointestinal stromal tumor on prognosis (P>0.05), age and nature of the tumor was gastrointestinal stromal tumor prognostic factors, the greater the age, The higher the degree of malignancy, the worse the prognosis (P<0.05). Conclusion Patients with gastrointestinal stromal tumors often have abdominal pain, bloody diarrhea, bloating and other symptoms, tumors were solitary nodule, CD117 and CD34 positive diffuse, SMA and S-100 was main focal distribution, older and a high degree of malignancy in patients with a poor prognosis, and gender, tumor size, clinical symptoms, staining does not affect the prognosis of GISTs. Therefore, patients experiencing abdominal pain, bloody diarrhea, bloating and other symptoms and treatment should cause enough clinical attention, and early detection and early treatment..