CAJ | 학술논문

目的：应用共聚焦激光扫描显微镜（CLSM）观察自体表皮移植治疗白癜风后的黑素细胞恢复状况。方法采用CLSM对白癜风皮损进行检测，选择镜下显示黑素细胞完全消失的皮损进行自体表皮移植，移植后1、3、6个月动态观察黑素细胞恢复状况。结果20例白癜风患者中，28块皮损进行了自体表皮移植，临床总成活率为96．43％，移植后CLSM成像显示黑素细胞完全恢复率为82．14％。结论 CLSM检测可作为白癜风自体表皮移植治疗适应证的选择方法，也可作为移植治疗后连续动态观察黑素细胞恢复状况的可靠手段。
목적：응용공취초격광소묘현미경（CLSM）관찰자체표피이식치료백전풍후적흑소세포회복상황。방법채용CLSM대백전풍피손진행검측，선택경하현시흑소세포완전소실적피손진행자체표피이식，이식후1、3、6개월동태관찰흑소세포회복상황。결과20례백전풍환자중，28괴피손진행료자체표피이식，림상총성활솔위96．43％，이식후CLSM성상현시흑소세포완전회복솔위82．14％。결론 CLSM검측가작위백전풍자체표피이식치료괄응증적선택방법，야가작위이식치료후련속동태관찰흑소세포회복상황적가고수단。
Objective To observe the changes of melanocytes in vitiligo after autologou epidermal grafting under confocal laser scanning microscope ( CLSM) .Methods CLSM was applied to detect the skin lesions of vitiligo;the lesions without melanocytes under CLSM were selected for autologou epidermal grafting and dynamic observation under CLSM was made for the changes of melanocytes 1, 3 and 6 months after grafting .Results 28 lesions in 20 cases with vitiligo were performed autologou epidermal grafting;the total clinical survival rate was 96.43%;the full recovery of melanocytes on CLSM imaging after grafting reached 82.14%.Conclusions CLSM detection can help the indication selection of autologous epidermal grafting for vitiligo and it is a reliable method of dynamic observation of melanocyte recovery after grafting .