CAJ | 학술논문

目的：观察华通胶间充质干细胞（ WJ-MHCs）移植对心肌梗死后心力衰竭的疗效。方法选择解放军303医院74例心肌梗死后心力衰竭的患者随机分为治疗组（37例）与对照组（37例），对照组只进行常规药物治疗，治疗组在常规药物治疗的基础上进行WJ-MHCs移植。检测各组治疗前及治疗后2 w及第2个月外周血浆N末端B型利钠肽原（NT-proBNP）水平，用心脏超声检测左室心功能指标，并记录严重不良临床事件。结果治疗及随访期间两组临床不良事件发生率差异无统计学意义。治疗后第2 w及第2个月，两组NT-proBNP较术前均有改善，但治疗组较对照组改善更显著（ P＜0．05）；治疗组治疗后第2个月LVEDV较治疗前显著减小（P＜0．05），其余左室心功能指标变化差异无统计学意义，而对照组各项指标治疗前后变化无统计学意义。结论 WJ-MHCs移植治疗心肌梗死后心力衰竭安全有效，可以显著降低患者的NT-proBNP水平。
목적：관찰화통효간충질간세포（ WJ-MHCs）이식대심기경사후심력쇠갈적료효。방법선택해방군303의원74례심기경사후심력쇠갈적환자수궤분위치료조（37례）여대조조（37례），대조조지진행상규약물치료，치료조재상규약물치료적기출상진행WJ-MHCs이식。검측각조치료전급치료후2 w급제2개월외주혈장N말단B형리납태원（NT-proBNP）수평，용심장초성검측좌실심공능지표，병기록엄중불량림상사건。결과치료급수방기간량조림상불량사건발생솔차이무통계학의의。치료후제2 w급제2개월，량조NT-proBNP교술전균유개선，단치료조교대조조개선경현저（ P＜0．05）；치료조치료후제2개월LVEDV교치료전현저감소（P＜0．05），기여좌실심공능지표변화차이무통계학의의，이대조조각항지표치료전후변화무통계학의의。결론 WJ-MHCs이식치료심기경사후심력쇠갈안전유효，가이현저강저환자적NT-proBNP수평。
Objective To observe the therapeutic effects of human umbilical cord Wharton 's jelly mesenchymal stem cells ( WJ-MSC) transplantation on heart failure of acute myocardial infarction .Methods 74 cases with heart failure of acute myocardial infarction in Hospital 303 of PLA were randomly divided into 2 groups:treatment group and control group ,37 in each.Drug therapy was applied to patients in both groups ,while WJ-MHCs transplantation was added to patients in treatment group .The detections were made to plasma NT-proBNP in the peripheral blood before treatment ,2 weeks and 2 months after treatment;and left ventricular function was evaluated by ultrasound;the severe adverse clinical events were recorded .Results The occurrence of adverse clinical events in treatment and follow-up period in the 2 groups was of no statistical difference;NT-proBNP of the patients in both groups 2 weeks and 2 months after treatment was more improved than that before treatment ,while the improvement in treatment group was more obvious than that in control group (P<0.05);LVEDV in treatment group 2 months after treatment decreased much more than that before treatment (P<0.05),and the changes of other index of left ventricular function were of no statistical significance ;the index before and after treatment in control group were of no statistical changes .Conclusions WJ-MHCs transplantation is safe and effective in treating heart failure of acute myocardial infarction and can greatly decrease the level of NT-proBNP of the patients .