CAJ | 학술논문

目的：观察替吉奥联合香菇多糖治疗老年胃癌的疗效。方法选择＞70岁的老年进展期胃癌患者27例，给予S-1（替吉奥）40～60 mg /m2口服，服药7 d后休息7 d，28 d为一个周期；香菇多糖2 mg静滴，2次/w；共用6个周期。结果全组患者均可评价疗效，部分缓解（PR）3例（11．11％），病变稳定（SD）17例（63．96％），进展（PD）7例（25．93％），临床受益率（DCR）为75％；无进展生存时间（PFS）5．8个月（95％可信区间3．7～7．9），总生存时间（OS）为11．8个月（95％可信区间6．1～17．5）。主要不良反应有贫血11例、白细胞减低8例、食欲下降13例和乏力6例，未影响治疗。结论替吉奥联合香菇多糖治疗老年胃癌疗效确切，耐受性良好，值得推广和进一步研究。
목적：관찰체길오연합향고다당치료노년위암적료효。방법선택＞70세적노년진전기위암환자27례，급여S-1（체길오）40～60 mg /m2구복，복약7 d후휴식7 d，28 d위일개주기；향고다당2 mg정적，2차/w；공용6개주기。결과전조환자균가평개료효，부분완해（PR）3례（11．11％），병변은정（SD）17례（63．96％），진전（PD）7례（25．93％），림상수익솔（DCR）위75％；무진전생존시간（PFS）5．8개월（95％가신구간3．7～7．9），총생존시간（OS）위11．8개월（95％가신구간6．1～17．5）。주요불량반응유빈혈11례、백세포감저8례、식욕하강13례화핍력6례，미영향치료。결론체길오연합향고다당치료노년위암료효학절，내수성량호，치득추엄화진일보연구。
Objective To evaluate the efficacy and toxicity of oteracil potassium ( S-1 ) combined with lentinan in elderly patients with advanced gastric cancer .Methods Twenty-seven elderly patients ( over 70 years of age ) with advanced gastric cancer received S-1(40-60 mg/m2,7 days of oral administration followed by 7 days of withdrawal,28 days for a cycle),as well as lentinan(2 mg iv drip,twice a week);there were a total of 6 chemotherapy cycles.Results Of all patients,3(11.11%) achieved a partial remission,17 ( 63.96%) had stable disease , and 7 ( 25.93%) had progressive disease;the clinical benefit rate was 75%.The progression-free survival was 5.8 months[95%confidence interval(CI)3.7-7.9 months].The overall survival was 11.8 months(95%CI 6.1-17.5 months).The main adverse reactions included anemia (11 cases),leucopenia(8 cases),poor appetite(13 cases),and fatigue(6 cases),but they did not affect treatment .Conclusions Chemotherapy with S-1 plus lentinan has good efficacy and is well tolerable in elderly patients with advanced gastric cancer ,and it is worthy of clinical application and further research .