CAJ | 학술논문

目的：使用间接法建立本实验室的CA72-4参考区间。方法回顾性研究。通过中山医院实验室信息系统采集数据库中自2010年1月至2011年12月的2460例体检人群的CA72-4检测结果。对数据进行正态转换后，使用“Stem-and-Leaf&BoxPlots”数学方式对数据进行剔除和入组。筛选入组的数据经过男、女性别组间差异检验和年龄相关性分析后，利用非参数排序法建立CA72-4的参考区间。结果经“Stem-and-Leaf＆BoxPlots”计算剔除数据139份，共入组2321份数据。其中男1548例，CA72-4结果为1.7（0.4～18.9）U/ml，女773例，CA72-4结果为1.8（0.2～18.9）U/ml。经统计，男、女不同性别组间CA72-4差异有统计学意义（Z＝-2.337，P＜0.05），需根据性别建立不同的CA72-4生物参考区间。男、女各组CA72-4结果与年龄无相关性（r＝-0.044、0.041，P值均＞0.05）。CA72-4的生物参考区间分别为男＜8.9U/ml，女＜11.6U/ml。结论使用间接法建立检验项目的生物参考区间是一种比较简便的方法，适用于实验室检验项目参考区间的定期评审和一些无法使用直接法建立参考区间的项目。
목적：사용간접법건립본실험실적CA72-4삼고구간。방법회고성연구。통과중산의원실험실신식계통채집수거고중자2010년1월지2011년12월적2460례체검인군적CA72-4검측결과。대수거진행정태전환후，사용“Stem-and-Leaf&BoxPlots”수학방식대수거진행척제화입조。사선입조적수거경과남、녀성별조간차이검험화년령상관성분석후，이용비삼수배서법건립CA72-4적삼고구간。결과경“Stem-and-Leaf＆BoxPlots”계산척제수거139빈，공입조2321빈수거。기중남1548례，CA72-4결과위1.7（0.4～18.9）U/ml，녀773례，CA72-4결과위1.8（0.2～18.9）U/ml。경통계，남、녀불동성별조간CA72-4차이유통계학의의（Z＝-2.337，P＜0.05），수근거성별건립불동적CA72-4생물삼고구간。남、녀각조CA72-4결과여년령무상관성（r＝-0.044、0.041，P치균＞0.05）。CA72-4적생물삼고구간분별위남＜8.9U/ml，녀＜11.6U/ml。결론사용간접법건립검험항목적생물삼고구간시일충비교간편적방법，괄용우실험실검험항목삼고구간적정기평심화일사무법사용직접법건립삼고구간적항목。
Objective To establish the reference interval for CA 72-4 in indirect method.Methods All results for CA72-4 that were stored in our laboratory information system of Zhongshan hospital between Jan.2010 and Dec.2012 were included in this study.Outliers were identified and omitted using Stem-and-Leaf&Box Plots in SPSS statistical software.The treated data was divided into several groups according to gender and age.Nonparametric rank sum test was used to observe the difference between male and female participants and Spearman correlation analysis was used to examine the correlation between CA 72-4 and age.Nonparametric reference intervals for CA 72-4 were estimated statistically in two gender sub-groups.Results After 139 cases excluded, there were 1 548 cases of male (Median 1.7, 0.4 to 18.9) and 773 cases of female ( Median 1.8, 0.2 to 18.9 ).There was a significant difference in serum CA 72-4 between male and female participants.No significant difference was found in serum CA 72-4 among age sub-groups.Indirect reference values for CA 72-4 of male and female were respectively 0 to 8.9 U/ml and 0 to 11.6 U/ml.Conclusion Indirect method to establish biological reference interval is a relatively simple and less expensive method under the high rapid development of the hospital information network .It can be used in the periodical review and establishing the reference intervals where the direct method can not be used.