中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
11期
1676-1677
,共2页
禤晓燕%杨爱成%梁子安%李杰峰%王宝安
禤曉燕%楊愛成%樑子安%李傑峰%王寶安
훤효연%양애성%량자안%리걸봉%왕보안
慢性肾小球肾炎%蛋白尿%前列地尔%缬沙坦
慢性腎小毬腎炎%蛋白尿%前列地爾%纈沙坦
만성신소구신염%단백뇨%전렬지이%힐사탄
Glomerulonephritis%Proteinuria%Alprostadil%Valsartan
目的 观察前列地尔联合缬沙坦治疗慢性肾小球肾炎蛋白尿的临床疗效.方法 将78例慢性肾小球肾炎蛋白尿患者采用数字表法随机分为两组,每组各39例,对照组采取常规治疗,观察组在此基础上加用前列地尔联合缬沙坦治疗,比较两组临床治疗效果.结果 观察组总有效率为92.31％,显著高于对照组的74.36％(x2 =9.825,P＜0.05);观察组治疗后24 h尿蛋白量、血尿素氮及血肌酐水平分别为(1.00±0.39) g/24 h、(7.11±0.15) mmol/L和(80.86±0.65) μmol/L,均显著低于对照组的(1.30±0.48)g/24 h、(9.18 ±2.21) mmol/L和(98.71±4.34) μmol/L(t=9.32、7.83、7.12,均P＜0.05).结论 前列地尔联合缬沙坦治疗慢性肾小球肾炎蛋白尿疗效显著,可明显缓解患者临床症状,改善其肾功能,值得推广应用.
目的 觀察前列地爾聯閤纈沙坦治療慢性腎小毬腎炎蛋白尿的臨床療效.方法 將78例慢性腎小毬腎炎蛋白尿患者採用數字錶法隨機分為兩組,每組各39例,對照組採取常規治療,觀察組在此基礎上加用前列地爾聯閤纈沙坦治療,比較兩組臨床治療效果.結果 觀察組總有效率為92.31％,顯著高于對照組的74.36％(x2 =9.825,P＜0.05);觀察組治療後24 h尿蛋白量、血尿素氮及血肌酐水平分彆為(1.00±0.39) g/24 h、(7.11±0.15) mmol/L和(80.86±0.65) μmol/L,均顯著低于對照組的(1.30±0.48)g/24 h、(9.18 ±2.21) mmol/L和(98.71±4.34) μmol/L(t=9.32、7.83、7.12,均P＜0.05).結論 前列地爾聯閤纈沙坦治療慢性腎小毬腎炎蛋白尿療效顯著,可明顯緩解患者臨床癥狀,改善其腎功能,值得推廣應用.
목적 관찰전렬지이연합힐사탄치료만성신소구신염단백뇨적림상료효.방법 장78례만성신소구신염단백뇨환자채용수자표법수궤분위량조,매조각39례,대조조채취상규치료,관찰조재차기출상가용전렬지이연합힐사탄치료,비교량조림상치료효과.결과 관찰조총유효솔위92.31％,현저고우대조조적74.36％(x2 =9.825,P＜0.05);관찰조치료후24 h뇨단백량、혈뇨소담급혈기항수평분별위(1.00±0.39) g/24 h、(7.11±0.15) mmol/L화(80.86±0.65) μmol/L,균현저저우대조조적(1.30±0.48)g/24 h、(9.18 ±2.21) mmol/L화(98.71±4.34) μmol/L(t=9.32、7.83、7.12,균P＜0.05).결론 전렬지이연합힐사탄치료만성신소구신염단백뇨료효현저,가명현완해환자림상증상,개선기신공능,치득추엄응용.
Objective To observe the clinical efficacy of alprostadil combined with valsartan in treatment of chronic glomerulonephritis proteinuria.Methods 78 patients with chronic glomerulonephritis proteinuria were randomly divided into two groups,and each group had 39 cases.The control group was given conventional treatment,while the observation group was given alprostadil combined with valsartan on the basis of the control group.The clinical outcomes were compared between the two groups.Results The total effective rate of the observation group was 92.31％,which was significantly higher than 74.36％ of the control group (x2 =9.825,P ＜ 0.05).After treatment,the 24h Upro,BUN and SCr of the observation group were (1.00 ± 0.39) g/24h,(7.11 ± 0.15) mmol/L and (80.86 ± 0.65) μmol/L,which were significantly lower than those of the control group [(1.30 ± 0.48) g/24h、(9.18 ± 2.21) mmol/L and (98.71 ± 4.34) μmol/L],the differences were statistically significant (t =9.32,7.83,7.12,all P ＜ 0.05).Conclusion Alprostadil combined with valsartan in the treatment of chronic glomerulonephritis proteinuria has significant effect,and it can significantly alleviate clinical symptoms,improve renal function,which should be widely applied in clinical.
