浙江大学学报(医学版)
浙江大學學報(醫學版)
절강대학학보(의학판)
JOURNAL OF ZHEJIANG UNIVERSITY MEDICAL SCIENCES
2014年
2期
234-239
,共6页
细胞因子类%炎症/病理生理学%烟酰胺磷酸核糖基转移酶%综述
細胞因子類%炎癥/病理生理學%煙酰胺燐痠覈糖基轉移酶%綜述
세포인자류%염증/병리생이학%연선알린산핵당기전이매%종술
Cytokines%Inflammation/physiopathology%Nicotinamide phosphoribosyltransferase%Review
烟酰胺磷酸核糖转移酶( Nampt )又称内脏脂肪素( Visfatin )和前B细胞克隆增强因子。研究发现,Nampt是催化烟酰胺腺嘌呤二核苷( NAD )合成的限速酶,也是一种脂肪因子、细胞因子,参与免疫、代谢和应激等相关生理病理过程;值得关注的是,Nampt参与了一系列与炎症相关的疾病,包括急性肺损伤、动脉粥样硬化、心肌梗死、肥胖、2型糖尿病、关节炎等,因而Nampt 被认为是炎症相关疾病的治疗药物开发新靶点。本文就Nampt在炎症中的作用研究进展作一综述。
煙酰胺燐痠覈糖轉移酶( Nampt )又稱內髒脂肪素( Visfatin )和前B細胞剋隆增彊因子。研究髮現,Nampt是催化煙酰胺腺嘌呤二覈苷( NAD )閤成的限速酶,也是一種脂肪因子、細胞因子,參與免疫、代謝和應激等相關生理病理過程;值得關註的是,Nampt參與瞭一繫列與炎癥相關的疾病,包括急性肺損傷、動脈粥樣硬化、心肌梗死、肥胖、2型糖尿病、關節炎等,因而Nampt 被認為是炎癥相關疾病的治療藥物開髮新靶點。本文就Nampt在炎癥中的作用研究進展作一綜述。
연선알린산핵당전이매( Nampt )우칭내장지방소( Visfatin )화전B세포극륭증강인자。연구발현,Nampt시최화연선알선표령이핵감( NAD )합성적한속매,야시일충지방인자、세포인자,삼여면역、대사화응격등상관생리병리과정;치득관주적시,Nampt삼여료일계렬여염증상관적질병,포괄급성폐손상、동맥죽양경화、심기경사、비반、2형당뇨병、관절염등,인이Nampt 피인위시염증상관질병적치료약물개발신파점。본문취Nampt재염증중적작용연구진전작일종술。
Nicotinamide phosphoribosyltransferase (Nampt) is also called visfatin or pre-B-cell colony-enhancing factor .The functions of Nampt have been reported as a cytokine , an adipokine and the rate-limiting enzyme in nicotinamide adenine dinucleotide biosynthesis .As a pleiotropic multifunctional protein , Nampt is involved in a variety of physiological and pathological conditions including innate immunity , metabolic disorders , and stress; and Nampt also participates in inflammatory disorders such as acute lung injury , atherosclerosis , myocardial infarct , obesity , type 2 diabetes , and rheumatoid arthritis .The studies indicate that Nampt might be a potential target for pharmacological intervention against inflammatory diseases . We review research advances on the roles of Nampt in inflammation .