CAJ | 학술논문

目的：研究结直肠癌淋巴结转移的影响因素。方法收集2007年1月至2012年1月行根治性手术的T3／T4结直肠癌临床病理资料，分析其对结直肠癌淋巴结转移的影响。应用SPSS 16．0统计软件进行统计学分析，采用卡方检验进行单因素分析，Logistic回归模型进行多因素相关分析， P＝0．05为检验水准。结果入组结直肠癌的淋巴结转移率为65．2％；单因素分析结果显示年龄（P＝0．041）、肿瘤大小（P ＝0．029）、大体类型（P ＝0．013）、分化程度（P＝0．009）、浸润深度（P＝0．002）及送检淋巴结数（P＝0．021）与淋巴结转移密切相关。多因素分析结果显示与结直肠癌淋巴结转移相关因素的相关程度依次递减为：浸润深度（ P ＝0．013， OR ＝2．708）、分化程度（P＝0．020， OR＝2．397）、大体类型（P ＝0．026， OR ＝2．330）、年龄（P ＝0．043， OR ＝2．089）。结论结直肠癌的浸润深度是淋巴结转移发生最主要因素。
목적：연구결직장암림파결전이적영향인소。방법수집2007년1월지2012년1월행근치성수술적T3／T4결직장암림상병리자료，분석기대결직장암림파결전이적영향。응용SPSS 16．0통계연건진행통계학분석，채용잡방검험진행단인소분석，Logistic회귀모형진행다인소상관분석， P＝0．05위검험수준。결과입조결직장암적림파결전이솔위65．2％；단인소분석결과현시년령（P＝0．041）、종류대소（P ＝0．029）、대체류형（P ＝0．013）、분화정도（P＝0．009）、침윤심도（P＝0．002）급송검림파결수（P＝0．021）여림파결전이밀절상관。다인소분석결과현시여결직장암림파결전이상관인소적상관정도의차체감위：침윤심도（ P ＝0．013， OR ＝2．708）、분화정도（P＝0．020， OR＝2．397）、대체류형（P ＝0．026， OR ＝2．330）、년령（P ＝0．043， OR ＝2．089）。결론결직장암적침윤심도시림파결전이발생최주요인소。
Objective To investigate the influential factors of lymph node metastasis in colorectal cancer. Methods The clinicopathological data of patients with colorectal cancer who had undergone radical resection from January 2007 to January 2012 were collected and analyzed by the chi-square test and logistic regression analysis using SPSS 16.0. Results The rate of lymph node metastasis in colorectal cancer was 65.2%.Age(P=0.041), tumor size(P=0.029), gross types(P=0.013), differentiation (P=0.009), tumor invasion depth (P =0.002) and ELN(P =0.021)between the 2 groups were significantly different .The results of logistic regression analysis showed the correlativity of risk factor of lymph node metastasis in colorectal cancer and the depth of tumor invasion (P=0.013, OR=2.708) >differentiation(P=0.020,OR =2.397) >gross types(P =0.026,OR =2.330) >age(P =0.043, OR=2.089). Conclusion The depth of tumor invasion is the key risk factor of lymph node metastasis in patients with colorectal cancer .