CAJ | 학술논문

目的：探讨维生素 D 对儿童血清25-羟维生素 D3[25-（OH）D3]、IgA、IgM、IgG 水平的影响及反复呼吸道感染（RRI）的治疗效果。方法选取2011年1月～2011年12月在我院儿科门诊就诊的 RRI 患儿113例，采用随机数字表法分为补维生素 D 组（57例）和观察组（56例），另选取同期健康体检的儿童为对照组（62例），补维生素 D 组和观察组均按呼吸道感染予常规治疗，补维生素 D 组另给予阿法骨化醇胶囊口服，对所有的 RRI 患儿随访1年，观察并记录呼吸道感染的复发次数，并检测三组不同时期血清25-（OH）D3、IgA、IgM、IgG 水平。结果补维生素 D 组和观察组治疗总有效率分别为96．49％、67．86％，差异有统计学意义（P ＜0．001）；治疗后补维生素 D 组患儿呼吸道感染次数明显减少，与观察组比较差异有统计学意义（P ＜0．001）；补维生素 D 组治疗后血清25-（OH）D3和 IgA、IgM、IgG 水平明显升高（P ＜0．01），观察组各项指标改变不明显（P ＞0．05），两组比较差异有统计学意义（P ＜0．01）。结论RRI 患儿存在血清25-（OH）D3低水平和体液免疫功能降低，适当地补充维生素 D 能调节机体免疫功能，减少呼吸道感染发生频率。
목적：탐토유생소 D 대인동혈청25-간유생소 D3[25-（OH）D3]、IgA、IgM、IgG 수평적영향급반복호흡도감염（RRI）적치료효과。방법선취2011년1월～2011년12월재아원인과문진취진적 RRI 환인113례，채용수궤수자표법분위보유생소 D 조（57례）화관찰조（56례），령선취동기건강체검적인동위대조조（62례），보유생소 D 조화관찰조균안호흡도감염여상규치료，보유생소 D 조령급여아법골화순효낭구복，대소유적 RRI 환인수방1년，관찰병기록호흡도감염적복발차수，병검측삼조불동시기혈청25-（OH）D3、IgA、IgM、IgG 수평。결과보유생소 D 조화관찰조치료총유효솔분별위96．49％、67．86％，차이유통계학의의（P ＜0．001）；치료후보유생소 D 조환인호흡도감염차수명현감소，여관찰조비교차이유통계학의의（P ＜0．001）；보유생소 D 조치료후혈청25-（OH）D3화 IgA、IgM、IgG 수평명현승고（P ＜0．01），관찰조각항지표개변불명현（P ＞0．05），량조비교차이유통계학의의（P ＜0．01）。결론RRI 환인존재혈청25-（OH）D3저수평화체액면역공능강저，괄당지보충유생소 D 능조절궤체면역공능，감소호흡도감염발생빈솔。
Objective To investigate the effect of Vitamin D on children serum 25-hydroxy vitamin D3 [25 (OH)D3 ],IgA,IgM and IgG and the efficacy in treatment of recurrent respiratory infection (RRI). Methods From January 2011 to December 2011,a total of 113 outpatients of RRI children from pediatric de-partment of our hospital were chosen and divided into a vitamin D supplement group (57 cases)and an observa-tion group (56 cases)by using the random number table method,meanwhile,62 children participated health physical examination at the same period were selected as the control group.Vitamin D supplement group and observation group were treated for respiratory tract infection routinely.In addition,Vitamin D supplement group were administered oral Alfacalcidol Capsule.One-year follow-up for RRI children was done.The fre-quency of respiratory tract infection recurrence were observed and recorded.Serum 25 (OH)D3 ,IgA,IgM and IgG levels of three groups at different time points were measured. Results The total effective rate of vitamin D supplement group and observation group were 96.49%、67.86%,respectively.The difference was statistical-ly significant (P <0.001).After treatment,respiratory tract infection frequency of children in vitamin D sup-plement group decreased significantly,compared with observation group,there was statistically significant difference (P <0.001).Serum 25 (OH)D3 ,IgA,IgM and IgG levels in vitamin D supplement group elevated significantly (P <0.01).The changes of indicators in observation group were quiet(P >0.05).Difference of two group was statistically significant(P <0.01). Conclusion The serum 25-(OH)D3 of RRI children was low and their humoral immune function decreased.Proper Vitamin D supplements could adjust the physical im-mune function and reduce respiratory infection frequency.